The reading is likely to show nonfarm payrolls grew by 205,000 jobs in February, less than half of the eye-popping 517,000 additions in January.
The unemployment rate is forecast to stay unchanged at 3.4%, the lowest since May 1969.
"The strength of the January jobs data came as a surprise to markets," said Mark Haefele Chief Investment Officer, UBS Global Wealth Management in a note.
ET, Dow e-minis were down 127 points, or 0.39%, S&P 500 e-minis were down 11.75 points, or 0.3%, and Nasdaq 100 e-minis were down 4.5 points, or 0.04%.
Among other stocks, Gap Inc (GPS.N) fell 6.7% in premarket trading after the apparel maker posted a bigger-than-expected fourth-quarter loss and forecast full-year sales below Wall Street estimates, signaling a slowdown in demand.