The US Federal Reserve Building is seen in Washington, DC, May 3, 2023.
However, the Fed did hint at a possible pause to hikes.
In Australia, the S&P/ASX 200 fell 0.24%, ahead of the country's March trade data due later Wednesday.
Futures for Hong Kong's Hang Seng index were also lower standing at 19,656, compared to its last close of 19,699.16.
Mainland Chinese markets are set to reopen after the Labor Day holiday, while Japanese markets are closed for a holiday Thursday.