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☆ With S&P back at new highs, now come the price target and earnings revisions
▼ + stars: | 2024-05-16 | by ( Bob Pisani | ) www.cnbc.com time to read: +4 min

Now that the S & P 500 and most major stock market indexes are at or near historic highs, expect a raft of earnings and year-end price target revisions for the S & P 500 to be coming. First up with an upward revision was Brian Belski at BMO Capital, who Wednesday raised his year-end S & P target to 5,600 from 5,100. The median price target (half above, half below) is 5,200. Earnings for the rest of the year have been remarkably stable, but the key point is that each quarter is higher and a record for S & P 500 profits: 2024 S & P 500 quarterly earnings estimates Q2: $59.46 (record) Q3: $63.49 (record) Q4: $65.08 (record) Source: LSEG Valuations (roughly 20 times forward S & P 500 earnings) are pricey but not unreasonable given the continuing strength of the economy and the prospects of AI-boosted returns. May: market advance broadens (advance/decline line) S & P 500: near new high S & P Mid Cap: new high S & P Small Cap: highest since Dec.

Persons: Sam Stovall, CFRA, Brian Belski, Belski, Subramanian, Venu Krishna, Goldman Sachs, David Kostin, Ned Davis, Ed Clissold, Oppenheimer, John Stoltzfus, Lori Calvasina, Manish, Nicolaus, Barry Banniester, Jonathan Golub, Chris Harvey, Dubravko, Bujas, Cantor Fitzgerald, Eric Johnson, Scott Chronert, Julian Emanuel, Fundstrat, Tom Lee, Morgan Stanley, Mike Wilson, Hugo Ste, Stovall Organizations: BMO Capital, Wall, of America, Barclays, BMO, RBC, Societe Generale, UBS, Bloomberg, Citigroup, Deutsche Bank, ISI, JPMorgan, Scotiabank, @VX Locations: Wells Fargo, Marie

☆ Market fear signals are flashing red as stocks pull back from record highs
▼ + stars: | 2024-04-16 | by ( Alex Harring | ) www.cnbc.com time to read: +4 min

Several major gauges of fear in the market are reflecting increased alarm from investors. @VX.1 1Y mountain The VIX over the past year At the same time, CNN's Fear and Greed Index has tipped into "fear" territory this week. Rising oil prices have also weighed on the stock market, as commodity traders bought in on expectations of escalating conflict in the Middle East. But he said the key threat to this outlook is if the conflict in the Middle East further spirals. "But, the caveat is, if things really go sideways in the Middle East, that could change the calculus."

Persons: Goldman Sachs, Alex McGrath, You've, Dow, Jason Heller, Heller Organizations: Federal Reserve, Nasdaq, Dow, Treasury, Coastal Wealth Locations: East, Iran, Israel

☆ AT&T says personal data from 73 million current and former account holders leaked onto dark web
▼ + stars: | 2024-03-30 | by ( Eva Rothenberg | ) edition.cnn.com time to read: +1 min

New York CNN —AT&T has launched an investigation into the source of a data leak that includes personal information of 73 million current and former customers. In a news release Saturday morning, the telecommunications giant said the data was “released on the dark web approximately two weeks ago,” and contains information such as account holders’ Social Security numbers. “It is not yet known whether the data … originated from AT&T or one of its vendors,” the company added. “Currently, AT&T does not have evidence of unauthorized access to its systems resulting in exfiltration of the data set.”The data seems to have been from 2019 or earlier. The company said the leak shows approximately 7.6 million current account holders and 65.4 million former account holders were affected.

Persons: ” Organizations: New, New York CNN —, ’ Social, CNN Locations: New York

☆ This sector offers defensive and growth properties – along with some portfolio income
▼ + stars: | 2024-02-26 | by ( Darla Mercado | Cfp | ) www.cnbc.com time to read: +6 min

The health-care sector of the S & P 500 is up about 8% year to date, marking a sharp comeback from a largely flat 2023. Even as health care is making a comeback this year, investors shouldn't forget its defensive attributes. Back in 2022, when the S & P 500 fell 19.4%, the health-care sector slipped only 3.5% "When markets are challenged, health care can be a good place to be," Lyons added. Some of them speak to the growth aspects of health care and why you can play offense." Merger activity is another driver of growth in health care, as large pharmaceutical companies snap up nimble biotech firms that are at the forefront of developing treatments.

Persons: Dan Lyons, Janus Henderson, shouldn't, Lyons, ImmunoGen, Seamus Fernandez, Sotatercept, Cigna, Cantor Fitzgerald, Sarah James, Fred Imbert Organizations: Big Tech, . Healthcare, Janus, Janus Henderson Investors, U.S . Food, Drug Administration's Center, Drug, Research, FDA, Esai, Pharmaceuticals, CNBC Pro, Merck, Abbott Laboratories, AbbVie, CVS Health Locations: U.S

☆ Vertex non-opioid painkiller shows positive results in critical late-stage trial on acute pain
▼ + stars: | 2024-01-30 | by ( Annika Kim Constantino | ) www.cnbc.com time to read: +3 min

Acute pain is usually caused by injury, surgery, illness, trauma or painful medical procedures and is likely to ease with time. Around 80 million patients are prescribed a medicine for their moderate-to-severe acute pain every year in the U.S., Vertex said in a release. Last year, the company's painkiller produced positive results in a mid-stage trial in diabetes patients suffering from a chronic nerve condition. Those two procedures are commonly used in studies of people with acute pain. Jefferies analyst Michael Yee said the drug's failure to meet that goal is in line with expectations and that overall, the late-stage trial results released Tuesday are positive.

Persons: Reshma Kewalramani, painkiller, Michael Yee Organizations: Vertex Pharmaceuticals, Food and Drug, Wall Street, CRISPR Therapeutics, Jefferies Locations: Boston, U.S

☆ Experimental Drug Cuts Off Pain at the Source, Company Says
▼ + stars: | 2024-01-30 | by ( Gina Kolata | ) www.nytimes.com time to read: +1 min

Vertex Pharmaceuticals of Boston announced Tuesday that it had developed an experimental drug that relieves moderate to severe pain, blocking pain signals before they can get to the brain. Vertex says its new drug is expected to avoid opioids’ potential to lead to addiction. In its clinical trials, Vertex measured the drug’s effect with a standard pain scale in which patients rated pain severity from 1 to 10, with 10 the most severe. Those taking its drug had a statistically and clinically meaningful reduction in pain, it reports. A third study looked at safety and tolerability of the drug in people experiencing pain from a variety of conditions.

Persons: midyear Organizations: Pharmaceuticals, Boston, Food and Drug Administration

☆ A bet that this monster rally is stalling out and this sector will start to suffer first
▼ + stars: | 2023-12-19 | by ( Nishant Pant | ) www.cnbc.com time to read: +4 min

The broad monster rally which started in November has shown no signs of stalling yet, but it will eventually. We'll present an options trade here to capitalize on that sector rotation, specifically how to bet against an industry likely to see outflows. If the healthcare sector keeps pulling back, most of the stocks in this sector will also tend to pull back. This is a lot of money for a mere $600 potential profit. Since I am paying a debit to buy the $420 call, it also reduces my profit potential to $155.

Persons: XLVwas, Nishant Pant Organizations: Vertex Pharmaceuticals

☆ It seems Microsoft realized asking why you want to close down OneDrive wasn't a great idea
▼ + stars: | 2023-11-10 | by ( Polly Thompson | ) www.businessinsider.com time to read: +4 min

A Microsoft software update forced some users to answer a survey before they closed OneDrive. It told The Verge in a statement: "Between Nov. 1 and 8, a small subset of consumer OneDrive users were presented with a dialog box when closing the OneDrive sync client, asking for feedback on the reason they chose to close the application. Perhaps Microsoft hoped the poll would reveal why some users don't like a system that offers only an all-or-nothing approach to storing files. AdvertisementAdvertisementPart of the problem has been Microsoft's insistence on pushing the clunky and unpopular OneDrive cloud storage system on users. X users were also not umimpressed with the change, with one pointing out that using Microsoft was "quickly becoming an abusive relationship."

Persons: —, Microsoft's OneDrive, I'm, they're, clingy, It's, We're, Clippy Organizations: Microsoft, Service

☆ The 16 most valuable global AI companies in sports, plus other takeaways from new data on VC investment in the sector
▼ + stars: | 2023-10-19 | by ( Margaret Fleming | ) www.businessinsider.com time to read: +6 min

While generative AI startups are attracting more investment overall, 2023 could be a notably slow year for venture capital investment in sports AI following several years of activity, according to new data from PitchBook. The year could mark the lowest level of investment in the sector since 2018 when PitchBook tracked just under $200 million in VC activity. Both those years had 114 VC investments, compared to just 54 in 2023 through mid-October, PitchBook data shows. These are the top 16 highest-valued sports AI companies globally in 2023, according to PitchBook:1) SigmaStar — $4.55 billion. The Beijing-based computer vision technology company offers solutions in sports and health, evaluating movement in real-time, according to its website.

Persons: PitchBook, Hudl, STATSports, Creatz, Ligatech, Simplebet, Zepp Organizations: Yi Technology, WSC Sports, Cleveland Cavaliers, Kakao, Arsenal FC, US, National Soccer Team, Duke University, Kansas City Chiefs, Ligatech, Tempus, Francisco's Tempus, Chelsea FC, NFL, Sports, NBA, MLS, Premier League, AI Research Locations: deepfakes, Beijing, Israel, New York, Korean, Europe, Mexico, Lincoln , Nebraska, Northern Ireland, Shanghai, PitchBook, Los Angeles, China, Vancouver

☆ Cramer says Vertex has a drug that may address the 'largest market opportunity in the world'
▼ + stars: | 2023-10-09 | by ( Kevin Stankiewicz | In Kevinstankiewicz | ) www.cnbc.com time to read: +1 min

CNBC's Jim Cramer on Monday suggested that investors keep an eye on Vertex Pharmaceuticals (VRTX), a biotechnology company developing a drug to treat acute pain that is not an opioid. They have a plan — Vertex," Cramer said on "Squawk on the Street." Vertex — which makes most of its revenue from cystic fibrosis treatment Trikafta — has late-stage trials underway for the pain drug, known as VX-548. "I do believe that if they have something, it would be the largest market opportunity in the world," Cramer said, adding that late-stage study results for VX-548 are expected "within the year." The firm, which has a buy-equivalent rating on Vertex shares, said it sees similarities between the current pain market and the obesity market one to two years ago.

Persons: CNBC's Jim Cramer, Cramer, —, Jim Cramer's, Eli Lilly, Mounjaro, Lilly Organizations: Vertex Pharmaceuticals, VX, Leerink Partners, Charitable Trust, CNBC, Club, U.S

The cybercrime group has made a ransom demand to MGM as well, those sources told CNBC's Contessa Brewer. The 8-K report, similar to one filed by MGM Resorts on Wednesday, acknowledges the hack as a material event. The cybercrime group demanded a $30 million ransom from Caesars, but the company ultimately agreed to pay about half that, sources said. Bloomberg previously reported the ransom and that the same group is behind the attacks on both companies. It wasn't immediately clear why Caesars delayed filing the report disclosing the hack and ransom for weeks.

Persons: CNBC's Contessa Brewer, Charles Carmakal Organizations: Caesars, CNBC, MGM, U.S . Securities, Exchange, MGM Resorts, Google, Bloomberg, vx, Twitter, Security, SEC Locations: United States, Twilio

☆ Biden says US destroys last of chemical weapons stockpile
▼ + stars: | 2023-07-07 | by ( ) www.reuters.com time to read: +2 min

WASHINGTON, July 7 (Reuters) - The U.S. has destroyed the last of its declared chemical weapons stockpile, President Joe Biden said on Friday, bringing to an end a decades-long effort to eliminate the deadly weapons first used on a large scale in World War One. As part of the Chemical Weapons Convention, which was ratified by the U.S. Senate in 1997, the U.S. and other signatories are required to destroy their chemical weapons stockpile by Sept. 30, 2023. The U.S. has been destroying its remaining stockpiles at U.S. Army Pueblo Chemical Depot in Pueblo, Colorado, and Blue Grass Army Depot (BGAD) in Richmond, Kentucky. "Chemical weapons are responsible for some of the most horrific episodes of human loss. Chemical weapons came to the fore during World War One, which became known as the "chemist's war."

Persons: Joe Biden, Biden, Mitch McConnell, Idrees Ali, Dan Whitcomb, Marguerita Choy Organizations: U.S, Chemical Weapons Convention, U.S . Senate, White, Army Pueblo Chemical, Blue Grass Army, The U.S, Centers for Disease Control, Senate Republican, United, Thomson Locations: U.S, United States, Pueblo , Colorado, Richmond , Kentucky, Kentucky, The, United Nations

☆ Investors are 'too complacent': Deutsche Bank strategist names two ways to hide from a potential downturn
▼ + stars: | 2023-07-06 | by ( Ganesh Rao | ) www.cnbc.com time to read: +4 min

Investors have become "too complacent" in the calm before a potential storm for stock markets, according to Deutsche Bank's Maximilian Uleer. Stock market volatility is usually indicated through the VIX index and is often considered a barometer of fear and uncertainty in the market. Downside protection for investors Uleer also highlighted a number of opportunities for investors to lock in their gains for this year. In the illustrated example above, the portfolio would suffer a maximum loss of 3.41% even if the stock market declined further, not accounting for trading costs, by mid-December. Potential upside Despite the near-term risks, the market strategist pointed to the travel and leisure sector for upside potential.

Persons: Deutsche Bank's Maximilian Uleer, It's, I'm, Uleer, CNBC's Organizations: Deutsche Bank's, Stock, PMI, Deutsche Bank, Uleer, Downside, Airlines Locations: China, Europe, Refinitiv

☆ Inside Dugway Proving Ground, where scientists work with the world's deadliest chemical and biological weapons in a top-secret military zone
▼ + stars: | 2023-07-04 | by ( James Pasley | ) www.businessinsider.com time to read: +1 min

Dugway Proving Ground is a sprawling army base in remote Utah. Despite those incidents, the army base mostly has a good safety record, according to the Pentagon. While the remote army base used to be responsible for creating chemical weapons — and, at one point, testing them on US soldiers — it now only analyzes them. A later report found that Dugway had failed to follow standard procedures — and use enough radiation — to kill the anthrax samples. The US is destroying its arsenal of chemical weapons, such as VX gas, to meet a treaty obligation that its entire stockpile is eliminated by September 30.

Persons: —, Dugway's, William E, King IV, Dugway Organizations: Pentagon, Service Locations: Utah, Korea

☆ Factbox: Iraq War: quotes from the conflict and its aftermath
▼ + stars: | 2023-03-15 | by ( ) www.reuters.com time to read: +9 min

BAGHDAD, March 15 (Reuters) - Here are some notable quotes from before, during and after the U.S.-led invasion of Iraq in March 2003 that toppled Saddam Hussein. - U.S. President George W. Bush referring to Iraq, Iran and North Korea in his State of the Union Address. - Saddam Hussein in message to U.N. General Assembly. - Saddam Hussein on first day of invasion. A lot of people put their reputations on the line and said the weapons of mass destruction is a reason to remove Saddam Hussein," - Bush.

Este vorba despre formarea „raidurilor” de drone, care marchează începutul unei noi ere în atacurile aeriene. Aceeaşi sursă a mai raportat atunci că alte drone „kamikaze”, Kubs, erau utilizate în Siria din 2019. Drona are o greutate maximă la decolare de 12 kilograme, cu o sarcină utilă de război de trei, și este echipată cu o aripă cruciformă. Dronele Lancet 3 ar rămâne, aşadar, să patruleze în zbor și, atunci când va apărea o dronă inamică, se vor arunca simultan asupra ei, detonând focosul. Moscova a fost extrem de impresionată de ceea ce s-a întâmplat în acel conflict și, în consecință, a dat un impuls programului contra-Uav, folosind dronele kamikaze pe post de “loitering munitions”.

Persons: drona, Drona Organizations: Statelor Unite, IS, Zala Aero Group, Zala Locations: China Lake, California, SUA, Statelor, Massachusetts, MIT, Siria, Rusia, Statele Unite, China, Turcia, Israel, Zala, Nagorno - Karabah, israeliană, Moscova

☆ Секретный яд: отравление Навального и единственное в России дело об убийстве «Новичком»
▼ + stars: | 2020-10-19 | by ( Роман Шлейнов | Илья Варламов Блогер | ) ava.md time to read: +27 min

В нашем распоряжении есть материалы уникального уголовного дела об убийстве банкира Ивана Кивелиди и его секретаря Зары Исмаиловой. А их проведение на серьезном уровне стало возможным благодаря возбуждению уголовного дела и быстрым действиям по сбору улик. В возбуждении уголовного дела было отказано. Даже малообъяснимая смерть политика в России давно не повод для возбуждения уголовного дела. О сужении зрачков и времени действия«В случае отравления Навального «Новичком» <...> ни до какого самолета он бы не дошел», — заявил Леонид Ринк в интервью РИА «Новости».

Persons: Xander, Bell, Forbes, Алексей Навальный, Навальный, Владимир Путин, Эммануэль Макрон, Иван Кивелиди, Зара Исмаилова, Кивелиди, Дмитрий Песков, Зару Исмаилов, Исмаилова, Юрий Щекочихин, Щекочихин, Сергей Нарышкин, Сергей Лавров, Анатолий Калиниченко, На, Путин, Узнав, Юрий Дудь, Леонид Ринк, Ринк, Эксперт-химик, Скрипалями, Александр Сабаев, Сабаев, Ольга Демичева, Ярослав Ашихмин, Кира Ярмыш, Михаил Фремдерман, Фремдерман, Виктор Шульга Organizations: Новичок, Организация по запрещению химического оружия, ФСБ, Росбизнесбанк, Новая газета, Бюро судебно-медицинской экспертизы, Департамент здравоохранения, Госдума, Яблоко, Служба внешней разведки, МИД, Центральная клиническая больница, Управление делами президента (ЦКБ), Городская клиническая больница № 1 (ГКБ), СМЭ, Шарите, Xander Hotel, РИА «Новости», ГосНИИОХТ, The Bell, ГУВД, Военная академия химзащиты, Экспертно-криминалистический центр, МВД, Институт проблем экологии и эволюции, РАН, Государственный НИИ органической химии и технологии, МВД (ЭКЦ МВД), ЭКЦ, Государственный НИИ органической химии и технологии (ГосНИИОХТ), Главное военно-медицинского управление, Минобороны, Военно-полевая терапия, Forbes, Европейская ассоциация по изучению диабета, Важные истории, BBC, Институт органической химии и технологии, Следственный комитет, Минздрав Locations: Германия, Швеция, Франция, Россия, Кремль, Москва, Берлин, Омск, Мытная улица, Кивелиди, Великобритания, США, Запад, Сибирский федеральный округ, Омская область, Израиль

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