The Environmental Protection Agency order requires Norfolk Southern to submit a work plan for EPA approval for the clean up associated with the Feb. 3 derailment.
Norfolk Southern shares were down 1.6% on Tuesday afternoon and have slid almost 11% since Feb. 3.
Norfolk Southern did not immediately reply for a request for comment on Shapiro's remarks.
Although no fatalities or injuries have been reported, residents have been demanding answers about health risks and blaming Norfolk Southern, state and federal officials for a lack of information regarding the crash.
Norfolk Southern said it had consulted with town leaders and was worried about the safety of its employees if they did attend.