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CNN —A 62-year-old man has died months after becoming the world’s first living recipient of a genetically edited pig kidney transplant, hailed as a medical milestone. Rick Slayman received the kidney at Massachusetts General in March after he had been diagnosed with end-stage kidney disease last year. “Our family is deeply saddened about the sudden passing of our beloved Rick but take great comfort knowing he inspired so many,” a family statement said. Before Slayman’s transplant, just two transplants using pig organs had been completed – both heart transplants performed under compassionate use. EGenesis, the biotech company providing the genetically edited pig kidney, called Slayman “a true pioneer” in a statement late Saturday night.

Persons: Rick Slayman, Mr, Slayman, Slayman’s, ”, “, Rick, –, ” Slayman, Tatsuo Kawai Organizations: CNN, Massachusetts General, Massachusetts Department of Transportation, Legorreta, Procurement, Transplantation Network, Massachusetts Locations: Massachusetts, ” Massachusetts

CNN —Rick Slayman, the world’s first living recipient of a genetically edited pig kidney transplant, was discharged from the hospital Wednesday, two weeks after his operation, Massachusetts General Hospital said in a statement. “He is recovering well and will continue to recuperate at home with his family,” the hospital said on X, formerly Twitter. Rick Slayman in his hospital room at Massachusetts General Hospital before his discharge on Wednesday April 3, 2024. Michelle Rose/Massachusetts General HospitalHis surgery is the third such xenotransplant of a pig organ into a living human. The first two transplants were hearts transplanted into living patients that had run out of other transplant options.

Persons: Rick Slayman, Slayman, I’ve, ”, Michelle Rose, Dr, Sanjay Gupta, ” Slayman Organizations: CNN, Massachusetts General Hospital, Massachusetts Department of Transportation, CNN Health, Procurement, Transplantation Network Locations: Massachusetts, U.S

☆ Scientists take ‘pioneering steps’ toward growing human kidneys in pigs
▼ + stars: | 2023-09-07 | by ( Katie Hunt | ) edition.cnn.com time to read: +8 min

CNN —Scientists have grown kidneys containing mostly human cells inside pig embryos, an important step toward growing kidneys and potentially other human organs that could be used for transplants in people. “The paper describes pioneering steps in a new approach to organ bioengineering using pigs as incubators for growing and cultivating human organs,” said Dusko Ilic, a professor of stem cell sciences at King’s College London, in a statement. “It is remarkable to see about 60% of the primordial pig kidney contained human cells,” Wu said. What the researchers didTo generate kidneys mostly composed of human cells in pigs, the scientists used cutting-edge techniques harnessing advances in stem cells, gene editing and embryology. “This (new) work is different from existing xenotransplantation approach and aims to generate organs mostly composed of human cells in pigs,” Wu said.

Persons: ”, Miguel Esteban, ” Esteban, “, Dusko Ilic, Jun Wu, Wu, ” Mary Garry, ” Wu, Esteban, ” Joseph A, Vassalotti, ” Vassalotti Organizations: CNN —, Guangzhou Institute of Biomedicine, Chinese Academy of Sciences, Procurement, Transplantation Network, King’s College London, University of Texas Southwestern Medical Center, University of Minnesota’s, Heart Institute, National Kidney Foundation, Icahn School of Medicine Locations: Health, United States, Mount Sinai

☆ Two research teams detail advancements in transplanting pig kidneys to humans, marking key steps on path to clinical trials
▼ + stars: | 2023-08-16 | by ( Deidre Mcphillips | ) edition.cnn.com time to read: +5 min

CNN —New advancements in transplanting pig kidneys to humans, detailed by two separate research teams on Wednesday, mark key steps forward in the evolving field of xenotransplantation, the use of non-human tissues or organs to treat medical conditions in humans. Both research teams used genetically modified pig kidneys that were transplanted into recipients experiencing brain death in what is considered pre-clinical human research. Other studies have demonstrated that this can occur when pig kidneys are transplanted in non-human primates. The team has been monitoring pig kidney transplants in a brain-dead decedent – a man named Maurice Miller, known as Mo, who died of a brain tumor – for nearly two months. “Over the last 20 years, we’ve gained a lot of information about how pig kidneys work to replace the functions in primates.

Persons: ”, Jayme Locke, Locke, ” Locke, NYU Langone, Maurice Miller, Mo, Robert Montgomery, Dr, Sanjay Gupta, “ We’re, Adam Griesemer, we’ve, ’ –, we’re Organizations: CNN, University of Alabama, Birmingham Heersink School of Medicine, New York University, Health, Comprehensive Transplant Institute, ”, UAB, NYU, NYU Langone Transplant Institute, CNN Health, Liver Transplant, FDA, US Department of Health, Human, Transplantation Network

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