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The Youngest Pandemic Children Are Now in School, and StrugglingThe pandemic’s babies, toddlers and preschoolers are now school-age, and the impact on them is becoming increasingly clear: Many are showing signs of being academically and developmentally behind. But the impact on the youngest children is in some ways surprising: They were not in formal school when the pandemic began, and at an age when children spend a lot of time at home anyway. Researchers said several aspects of the pandemic affected young children — parental stress, less exposure to people, lower preschool attendance, more time on screens and less time playing. The youngest students’ performance is “in stark contrast” to older elementary school children, who have caught up much more, the researchers said. Sarrah Hovis, a preschool teacher in Roseville, Mich., has seen plenty of the pandemic’s impact in her classroom.

Persons: ” “, “, ”, Jaime Peterson, —, Joel Ryan, Kristen Huff, Catherine Monk, ” David Feldman, Tommy Sheridan, don’t, Michaela Frederick, She’s, weren’t, Aaron Hardin, Frederick, Lissa O’Rourke, Sarrah, ” Terrance Anfield, children’s, Rahil, Briggs, Zero, Kelsey Schnur, Finley, Schnur, Analilia Sanchez, lockdowns, Heidi Tringali, Travis Dove, Tringali, I’m, Michael LoMedico, Emily Sampley, It’s, Dani Dumitriu Organizations: ”, Oregon Health, Science University, Curriculum Associates, Columbia, Start, Brook Allen, The New York Times, Associates, Cincinnati Public Schools, Cincinnati Children’s Hospital, The New York Locations: School, Washington State, U.S, St, Petersburg, Fla, Martin , Tenn, Sharon, Tenn, Augustine, Cincinnati, Roseville, Mich, “, Indianapolis, Sharpsville, Pa, El Paso, Charlotte, N.C, Yonkers, N.Y, Sioux Falls, S.D, Tennessee, Oregon

☆ Experimental gene therapy restores some vision in patients with inherited blindness
▼ + stars: | 2024-05-06 | by ( Jacqueline Howard | ) edition.cnn.com time to read: +16 min

“Now, post-surgery and post recovery, I am able to see in dimmer lighting with my left eye,” Cook said. A treatment that used CRISPR was found to be safe and efficacious in improving vision among a small sample of patients with inherited blindness in the Phase 1/2 clinical trial that Cook participated in. Months following the treatment, Cook was sitting with friends on a balcony that had Christmas lights wrapped around the railing. Courtesy Olivia CookBefore the treatment, Cook said that she sometimes could conceal the vision challenges she has had. Mass Eye and EarKalberer described the CRISPR treatment as “groundbreaking,” but warned it’s not a cure.

Persons: Olivia Cook, Cook, ”, ” Cook, “, I’ve, “ I’d, you’d, CRISPR, Eric Pierce, Brigham, “ We’re, ” Pierce, Jason Comander, ‘, Michael Kalberer, Kalberer, it’s, “ It’s, It’s, Pierce, Editas, We’re, Art Caplan, ” Caplan, —, Vlad Diaconita, ” Diaconita, Dr, Sanjay Gupta, Aliaa Abdelhakim Organizations: CNN, Missouri State University, New England, of Medicine, Mass, Harvard Medical School, Editas Medicine, Perelman School of Medicine, University of Pennsylvania, University of Michigan, University of Miami, Oregon Health & Science University, US Food and Drug Administration, CEP290, pharma, NYU Grossman School, Medicine’s Department of Population Health, Columbia University Vagelos College of Physicians and Surgeons, CNN Health Locations: Springfield, United States, CEP290

Accounts of suicidal thoughts linked to this class of drugs are drawing increasing scrutiny, including an investigation by European regulators announced in July. More than half of the narrative summaries describe suicidal thoughts appearing shortly after the person started the medicine or increased the dose. Wegovy’s U.S. prescribing label, produced with FDA approval, says suicidal thoughts or attempts have been reported in clinical trials for other weight-loss medicines. Sanofi's Acomplia, which never won U.S. approval, was withdrawn in Europe in 2008 after being linked to suicidal thoughts. She said she has not experienced any suicidal thoughts on that drug.

Persons: Dawn Heidlebaugh, Megan Jelinger, ”, Heidlebaugh, Eli Lilly, Thomas J, Moore, aren't, It’s, Novo, Dr, Erick Turner, Turner, Novo’s, drugmakers, Sanofi's, Sanofi, Contrave, John Amos, Lilly, Reuters weren’t, Lisa Wood, ” Wood, Sarah Sobol, you’re, Sobol, ’ ” Katherine, Jayson Chesnutt, Chesnutt, Robin Respaut, Chad Terhune, Maggie Fick, Ludwig Burger, Michele Gershberg, Brian Thevenot Organizations: REUTERS, Novo, U.S . Food, Drug Administration, Reuters, FDA, Johns Hopkins Bloomberg School of Public Health, Oregon Health & Science University, Novo Nordisk, U.S ., European Union, European Medicines Agency, U.S, Currax Pharmaceuticals, Vivus, Facebook, Thomson Locations: Findlay , Ohio, U.S, Ohio, Novo, Canada, Europe, Carolina, Buffalo , New York, North Carolina, Indiana

☆ How Bad Is a Second (or Third or Fourth) Case of Covid?
▼ + stars: | 2023-08-17 | by ( Dani Blum | More About Dani Blum | ) www.nytimes.com time to read: +2 min

Reinfection and long CovidThe chances you will get long Covid from a reinfection are fairly unpredictable — several experts interviewed for this story used the metaphor of Russian roulette. The milder your symptoms, the less likely you are to get long Covid, said Dr. Peter Chin-Hong, an infectious disease specialist at the University of California, San Francisco. But every time you get infected, no matter the severity, there is always a chance that you can develop longer-term symptoms. Dr. Sala said he frequently sees patients who were more or less fine after their first couple of infections wind up with long Covid in the wake of a third or fourth infection. Still, it’s not a foregone conclusion that reinfection definitively raises the risk of long Covid, said Fikadu Tafesse, a virologist at Oregon Health & Science University.

Persons: Peter Chin, Ziyad Al, Aly, Sala, that’s, ”, it’s, reinfection, Fikadu Tafesse, “ Organizations: University of California, Nature Medicine, U.S . Department of Veterans Affairs, Louis Healthcare, Oregon Health & Science University Locations: San Francisco, St

☆ Galym Imanbayev went from Stanford School of Medicine to venture capital. Here's why he says his medical training has been so crucial to becoming an investor at Lightspeed.
▼ + stars: | 2023-06-30 | by ( Samantha Stokes | ) www.businessinsider.com time to read: +8 min

During his senior year of high school, Imanbayev discovered another interest, entirely by chance. After mistiming his MCAT, Imanbayev faced one gap year before he could start medical school. As he jumped into the grueling demands of medical school, Imanbayev said that for everything he studied, there were additional things he wanted to add on and learn. Helping Lightspeed push into healthtech investingSince 2020, Imanbayev has been a partner at Lightspeed focusing on the health sector. Imanbayev himself has spearheaded investments for Lightspeed in the healthcare-equity startup Soda Health and the virtual-care startup Wheel.

Persons: Galym Imanbayev, he'd, Mark Zuckerberg, Larry Ellison, Jack Dorsey, Imanbayev, Imanbayev's, Dean Lloyd Minor's Organizations: Stanford, VC, Lightspeed Venture Partners, Co, Oregon Health & Science University, Martis, Stanford School of Medicine, Stanford Graduate School of Business, Lightspeed, Ancora Biotech, Soda Health Locations: Kazakhstan, Soviet Union, Portland , Oregon

☆ Cognitive decline accelerates after heart attack, study finds
▼ + stars: | 2023-05-30 | by ( Sandee Lamotte | ) edition.cnn.com time to read: +4 min

However, age-related cognitive decline is quite different from Alzheimer’s disease and other dementias and should not be confused with those, experts say. During the course of the research, however, over 1,000 of the participants had an acute myocardial infarction, or heart attack. Past studies found linkThis isn’t the first study to find a connection between accelerated cognitive decline and heart attacks, Smith and Silbert noted. As in the new study, people with heart attacks or angina (chest pain) had annual rates of cognitive decline before the attack similar to those of people who never had a heart attack, but then experienced accelerated cognitive decline, they added. Possible explanations may include depression after having a heart attack, which has been linked to dementia, they said.

Persons: What’s, Eric Smith, Lisa Silbert, Smith, ” Smith, Silbert, ” Organizations: CNN, Cognitive Neurosciences, University of Calgary, Oregon Health & Science University School of Medicine, Aging Locations: United States, Alberta, Portland, White

For decades doctors have been telling their patients that high levels of HDL, otherwise known as “good cholesterol,” could protect them from heart disease. But a new study suggests that having a lot of so-called good cholesterol doesn’t mean a lower risk of heart attacks. The new findings surprised the researchers, who originally designed their study to understand how cholesterol levels in Black and white middle-aged adults without heart disease affected their future risks. Previous research on "good" cholesterol and heart disease consisted of mostly white adults. Low HDL levels were associated with an increased risk of coronary heart disease in white participants, but not Black participants.

☆ Study suggests that HDL or ‘good’ cholesterol is less beneficial than previously thought, especially for Black adults
▼ + stars: | 2022-11-21 | by ( Deidre Mcphillips | ) edition.cnn.com time to read: +3 min

Also, higher levels of HDL cholesterol were not found to reduce the risk of cardiovascular disease for either group. “It’s been well accepted that low HDL cholesterol levels are detrimental, regardless of race. The researchers found that high levels of low-density lipoprotein (LDL) cholesterol and triglycerides “modestly” predicted heart disease risk among both Black and White adults. But they suggest that more work is needed to understand what’s driving the racial differences in the link between HDL and heart disease risk. And in the meantime, current clinical assessments for heart disease risk “may misclassify risk in Black adults, potentially hindering optimal cardiovascular disease prevention and management programs for this group,” they wrote.

☆ Predictive value of 'good' cholesterol level varies by race, U.S. study finds
▼ + stars: | 2022-11-21 | by ( Nancy Lapid | ) www.reuters.com time to read: +3 min

In contradiction to what has generally been assumed, low HDL levels did not confer any higher risk of heart disease in Black people, researchers said. Among white people, however, those with HDL levels below 40 milligrams per deciliter had a 22% higher risk for coronary heart disease compared with those whose HDL levels were higher. High HDL levels (above 60 mg/dL), which are thought to be protective, were not linked with lower coronary heart disease risks in either race, researchers found. Participants of both races were similar in age, cholesterol levels, and other heart disease risk factors, the researchers said. The early studies that shaped perceptions about healthy cholesterol levels overwhelmingly involved white American participants, Pamir said.

☆ Malaysia votes in general election, Anwar expected to lead tight race
▼ + stars: | 2022-11-19 | by ( A. Ananthalakshmi | Rozanna Latiff | ) www.reuters.com time to read: +4 min

Malaysians queue to cast their vote for the country's general election at Permatang Pauh, Penang, Malaysia November 19, 2022. Without a clear winner, political uncertainty could persist as Malaysia faces slowing economic growth and rising inflation. “I don’t think it is possible for any coalition to win on their own,” said Sivamurugan Pandian, political analyst at Malaysia Science University. Anwar was the top choice for prime minister at 33%, followed by Muhyiddin at 26% and Ismail at 17%. Sheila Supramaniam, 30, said she will vote for Anwar as his coalition stood firmly against corruption and discrimination.

☆ Covid vaccine trials didn't monitor menstrual changes. Researchers say it's part of a bigger problem.
▼ + stars: | 2022-11-17 | by ( Https | Media-Cldnry.S-Nbcnews.Com Image Upload Newscms Aria-Bendix-Byline-Jm.Jpg | Aria Bendix | ) www.nbcnews.com time to read: +6 min

Although they made up around half the participants in Covid vaccine trials, women were not asked about any menstrual changes as part of that process. Since then, several studies have revealed that Covid vaccines can indeed induce short-term changes in menstrual cycles. A 2021 study found that just eight out of 45 clinical trials that tested Covid vaccines and therapies separated results based on sex. In the past, menstrual changes have also been reported among those who received vaccines for typhoid, hepatitis B and influenza. Researchers don't know why post-vaccine menstrual changes occur.

Bogenschutz and his team specifically set out to test whether or not psilocybin, in addition to sessions of therapy, could cut cravings and help people with alcohol use disorder stay sober. Earlier research from institutions around the world has indicated that psilocybin has the potential to treat a variety of addiction disorders, including alcohol use disorder, opioid use disorder and addiction to smoking. Jon KostasWhen he began the psilocybin trial at age 25, he was consuming almost 23 drinks in a single bender. At the beginning of the first dose sessions, participants were given eye masks and headphones that played classical music. Bogenschutz said the rule of thumb with alcohol addiction treatment is that about one-third of patients who seek treatment will get better.

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