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Amgen is among the leaders of a pack of drugmakers racing to join the market with their own weight loss treatments. Amgen's drug, MariTide, is taken less frequently than Novo Nordisk's Wegovy and Eli Lilly's Zepbound, and may cause longer-lasting weight loss than the market leaders' injections. Novo Nordisk and Eli Lilly are also working on new weight loss drugs. The competition for a slice of the weight loss market has only grown more fierce in recent months. An injection pen of Zepbound, Eli Lilly’s weight loss drug, is displayed in New York City, U.S., December 11, 2023.
Persons: NOVO.B, Scott Olson, Eli Lilly, Nordisk's Wegovy, Eli Lilly's Zepbound, Amgen, William Blair, Matt Phipps, Bob Bradley, Boehringer Ingelheim, Phipps, Zepbound, Chris Schott, MariTide, Mario Tama, he's, Eli Lilly drugs, CagriSema, Eli Lilly’s, Brendan McDermid, Boehringer, Ingelheim, survodutide, Pascal Soriot, Christopher Furlong, dealmaking, David Denton Organizations: New, Halstead Pharmacy, Getty, Novo Nordisk, Nordisk's, William Blair & Company, CNBC, Therapeutics, AstraZeneca, Zealand Pharma, MariTide, Reuters, GLP, Pfizer, Eccogene Locations: Chicago , Illinois, Novo, Amgen, Thousand Oaks , California, New York City, U.S, Zealand, Macclesfield
Uses Electricity They’re delivering solar power after dark in California and helping to stabilize grids in other states. Peak demand average daily generation, by fuel type Peak demand 25k 25k megawatts megawatts Imports 20k 20k 15k 15k Gas Solar power Batteries Solar power 10k 10k Wind 5k 5k Hydro Nuclear 0 0 12a.m. Peak demand average daily generation, by fuel type Peak demand 25k 25k megawatts megawatts Imports 20k 20k 15k 15k Gas Solar power Batteries Solar power 10k 10k Wind 5k 5k Hydro Nuclear 0 0 12a.m. Ga. Ga. Texas Texas La. By The New York TimesMost grid batteries use lithium-ion technology, similar to batteries in smartphones or electric cars.
Persons: , , Helen Kou, Conn ., Mo ., R.I, Conn . Conn ., . Kan ., , Andrés Gluski, Mike Blake, John Phipps, Phipps, Stephanie Smith, Aaron Mitchell, Natalie McIntire, Tamir Kalifa, Emma Konet, Max Kanter, BloombergNEF, you’ve, Meredith Fowlie, Nate Blair, “ We’re, Ross D Organizations: Hydro Nuclear, Hydro, The New York Times, , United States U.S, Conn . Pa . Iowa Neb, N.J . Ohio Nev, Del . Utah Ill, Texas, Fla ., Vt, Wis ., Wis . Idaho Idaho S.D, Pa . Iowa Iowa Neb, Neb . N.J . N.J . Ohio Ohio Nev, Del . Utah Utah Ill, . Energy, AES Corporation, Reuters, California, Georgia Power, Natural Resources Defense Council, Nationwide, The New York Times Grid, University of California, National Renewable Energy Laboratory, Franklin, Associated Locations: California, The New York Times California, China, Texas , California, Arizona, Wash . Maine, Minn, Ore, N.H, N.Y, Mass, Wis . Idaho S.D, Mich, Wyo, R.I, Conn, Conn . Pa . Iowa, N.J . Ohio, Del . Utah, Calif, Md, Colo, W.Va . Va, Mo, Mo . Kan, Ky, N.C, Tenn, Ariz, ., S.C . California, Ala, Miss ., Fla, Alaska Texas, Hawaii, Wash . Maine Maine Mont, Mont, Vt, Wis, Wis . Idaho Idaho, S.D . Mich, Conn . Conn, Conn . Conn . Pa, Pa . Iowa, Neb . N.J . N.J . Ohio, Nev . Ind, Ind, Del, W.Va, W.Va . Va . Va, . Kan . Kan, S.C . Ala . Ala . Miss, . Texas Texas, La, Fla . Alaska Alaska Hawaii Hawaii California, Texas, Menifee, . California, ” In Texas, Fort Worth, West Texas, Georgia, Sweetwater , Texas, Tierra, Berkeley, Sacramento
That fueled investor concerns about new competition in the rapidly growing weight loss drug industry, sending shares of the current obesity players, Novo Nordisk and Eli Lilly , lower on Friday. Eli Lilly shares dropped nearly 3%, while Novo Nordisk's U.S.-traded shares fell more than 1%. Still, investors were pleased with Eli Lilly on Tuesday after the company assured them it can overcome ongoing supply constraints for its popular drugs. Eli Lilly hiked its full-year guidance in part due to optimism around increased production of Zepbound, its diabetes injection Mounjaro and similar drugs for the rest of the year. That signals Novo Nordisk is struggling to meet demand for the treatment.
Persons: Amgen, Eli Lilly, Bob Bradway, Bradway, Jay Bradner, autoinjector, Novo Nordisk's Wegovy, Eli Lilly's Zepbound, William Blair, Matt Phipps, Michael Yee, Amgen's Bradway, Karsten Munk Knudsen Organizations: Novo Nordisk, Novo Nordisk's, Jefferies, MariTide, Nordisk Locations: Novo Nordisk's U.S, North Carolina, Indiana, Ireland, Germany, U.S
Jenna Phipps and Nick Volkov bought this abandoned property in Vancouver with plans to turn it into their forever home. Jenna Phipps and Nick VolkovThe house was so dilapidated that the realtor had the couple sign a waiver before entering. The house was valued at $3.4 million CAD or $2.5 million USD with an asking price of $2.6 million CAD or $1.9 million USD. The original house was built in 1961 and had been abandoned for years before the couple bought it in 2024. Jenna Phipps and Nick Volkov
Persons: Jenna Phipps, Nick Volkov, Phipps, Volkov Organizations: CNBC, Royal Bank of Canada Locations: Vancouver, Vancouver , British Columbia, Canada
Mario Tama | Getty ImagesAmgen is taking a new approach as it tries to stand out in a crowded field of drugmakers racing to develop the next blockbuster weight loss drug. It's too early to say how competitive Amgen will be in the budding weight loss drug space, which Novo Nordisk and Eli Lilly have so far dominated. Goldman Sachs also projects that between 10 million and 70 million Americans will be taking weight loss drugs by 2028. The sustained weight loss in Amgen's study appears to contrast with results seen in clinical trials on Zepbound and Wegovy. An injection pen of Zepbound, Eli Lilly’s weight loss drug, is displayed in New York City, U.S., December 11, 2023.
Persons: Mario Tama, Eli Lilly, Goldman Sachs, Zepbound, Eli Lilly's, Amgen's MartiTide, Caroline Apovian, Apovian, Joe Buglewicz, MariTide, Holly Lofton, Eli Lilly’s, Brendan McDermid, Reuters Amgen's, William Blair, Matt Phipps, Phipps Organizations: Getty, Novo Nordisk, Pfizer, Viking Therapeutics, Therapeutics, Zealand Pharma, Boehringer, Center, Weight Management, Wellness, Brigham, Women's, Washington Post, NYU Langone Health, Reuters, William Blair & Company, CNBC Locations: Thousand Oaks , California, Oaks , California, Novo, New York City, U.S
Here are five types of foods that doctors and nutritionists eat every day for stellar brain health, heart health, longevity and overall wellness. Blueberries, in particular, are what longevity researcher, Neil Paulvin, refers to as the "holy grail" of longevity foods. They're also great for eye health, muscle recovery, brain health and strengthening your cells, he adds. All berries get their color from flavonoids which are a group of phytonutrients that have been linked to improvements in brain health and a reduction in cognitive decline. They're high in protein, fiber, antioxidants and minerals like magnesium and iron, Heller told CNBC Make It in 2022.
Persons: We've, Deepak Chopra, Neil Paulvin, Paulvin, They're, Mary Ellen Phipps, Uma Naidoo, Dr, Elizabeth Klodas, Samantha Heller, Heller, Lisa Genova, Naidoo Organizations: Harvard, CNBC Locations: Sunflower
download the appSign up to get the inside scoop on today’s biggest stories in markets, tech, and business — delivered daily. Read previewA couple of months behind bars didn't stop Martha Stewart from partaking in one of her favorite hobbies. People obtained an exclusive clip from a new CNN miniseries, "The Many Lives of Martha Stewart," in which several people recounted what it was like being in prison with Stewart. She served five months in Federal Prison Camp Alderson in West Virginia and another two years of supervised release. A representative for Stewart did not immediately respond to a request for comment from BI sent outside regular business hours.
Persons: , Martha Stewart, Stewart, Meg Phipps, Martha, Phipps, we're, Snoop Dogg Organizations: Service, CNN, Federal, Business, Cannes Lion, BI Locations: Alderson, West Virginia
Bristol Myers Squibb's Eliquis is a blood thinner used to prevent clotting, to reduce the risk of stroke. Bristol Myers Squibb's Opdivo is an immunotherapy used to treat cancers, including melanoma and lung cancer. Investors will get updates on Merck and Bristol Myers Squibb's plans for the years ahead when they report earnings on Thursday and Friday, respectively. That's unlike generics, which are cheaper copycats of small-molecule drugs like Bristol Myers Squibb's Eliquis. Bristol Myers Squibb is also testing a new form of Opdivo, which is currently administered into a patient's veins.
Persons: Johnson, William Blair, Matt Phipps, Bristol Myers, Johnson's, Merck's Keytruda, J's Stelara, Opdivo, Phipps, biosimilars, Eliquis, Biosimilars, Humira, JB Reed, Samsung's, Piper Sandler, Christopher Raymond, AbbVie, Raymond, Chris Schott, Schott, Robert Davis, Keytruda, Davis, JPMorgan's Schott, Bristol Myers Squibb, George Frey, J, Amgen, J confidentially, Mike Perrone, It's, Anna Moneymaker Organizations: New York Stock Exchange, Johnson, NYSE Big, Bristol Myers Squibb, Merck, Biden, William Blair & Company, CNBC, Guggenheim, Bristol, Leerink Partners, Bloomberg, Getty, Bioepis, JPMorgan, JPMorgan Health Care, Moderna, Bristol Myers, Karuna Therapeutics, Hardy, Huntsman Cancer Institute, University of Utah, Reuters, Teva Pharmaceuticals, Pharma, U.S . Department of Health, Human Services Locations: drugmakers, EY, Europe, U.S, Cambridge , Massachusetts, Arda, EY's Americas, Bristol, Salt Lake City , Utah, Washington , DC
The S&P 500 (.SPX), the Nasdaq (.IXIC) and the Dow (.DJI) registered their third straight week of gains. For the week, the S&P 500 added 2.2% while the Nasdaq composite rose 2.4% and the Dow climbed 1.9%. Traders work on the floor at the New York Stock Exchange (NYSE) in New York City, U.S., November 15, 2023. REUTERS/Brendan McDermid Acquire Licensing RightsEnergy, finishing up 2.1%, was the biggest percentage gainer among the 11 major S&P 500 sectors as oil prices settled up more than 4%. The S&P 500 posted 18 new 52-week highs and 1 new lows; the Nasdaq Composite recorded 55 new highs and 97 new lows.
Persons: Michael Barr, Mary Daly, Susan Collins, Robert Phipps, Per Stirling's Phipps, Dow, Jack McIntyre, Brendan McDermid, Russell, Rick Wilmer, Sinéad Carew, Shristi, Maju Samuel, Pooja Desai, David Gregorio Our Organizations: Dow, Nasdaq, Federal, San Francisco Fed, Boston Fed, Applied Materials, U.S . Justice, Stirling, Dow Jones, Brandywine Global, Traders, New York Stock Exchange, REUTERS, Rights Energy, Technology, Microsoft, Ross Stores, Old Navy, ChargePoint Holdings, NYSE, Thomson Locations: U.S, China, Austin Texas, Philadelphia, New York City, New York, Bengaluru
Third quarter sales of Horizon's gout drug Krystexxa rose to $253 million from $192 million. Amgen raised its post-acquisition forecast for full-year sales to between $28 billion and $28.4 billion from a previous estimate of $26.6 billion to $27.4 billion. Total revenue for the quarter rose 4% to $6.9 billion, in line with analyst expectations. Sales of cancer drug Lumakras fell 31% to $52 million and sales of psoriasis drug Otezla fell 10% to $567 million. Sales of Amjevita, Amgen's new biosimilar version of AbbVie's (ABBV.N) blockbuster arthritis drug Humira, rose 30% to $152 million.
Persons: Robert Galbraith, Amgen, Jefferies, Michael Yee, Bill Smead, Tepezza, We're, we've, Peter Griffith, AMG340, William Blair, Matt Phipps, Lumakras, Otezla, Deena Beasley, Leroy Leo, Bill Berkrot Organizations: REUTERS, Horizon Therapeutics, Smead Capital Management, Wall Street, U.S . Federal Trade Commission, Thomson Locations: South San Francisco , California, California, Los Angeles, Bengaluru
So before tip-off, here is everything you need to know ahead of the new NBA season. How to watchThe 78th NBA regular season will begin on Tuesday, October 24, running until Sunday, April 14, 2024. Games will be broadcast across TNT, ESPN, ABC, NBA TV and ESPN Radio in the US over the season, while NBA TV and NBA League Pass will broadcast games internationally. The dominant talking point of the NBA offseason was what color jersey Damian Lillard would be putting on this season. Holiday dribbles during the second half of the Celtics' preseason game against the New York Knicks.
Persons: There’s, Damian Lillard, Lillard, Giannis Antetokounmpo, Antetokounmpo, Adam Pantozzi, “ I’ve, I’ve, , Giannis, , Sarah Phipps, , Jayson Tatum, Jaylen Brown, Porziņģis, Joe Mazzulla, Maddie Meyer, , Joel Embiid, Nikola Jokić, Jamal Murray, Bruce Brown, Jeff Green, Bradley Beal, Devin Booker, Kevin Durant, Durant’s, didn’t, Beal, Frank Vogel, who’s, Larry O’Brien, Ja Morant, – Kawhi Leonard, Paul George –, Zion Williamson, Victor Wembanyama, Frenchman, Wembanyama, Gregg Popovich, LeBron James, Garrett Ellwood, Oklahoma City Thunder’s Chet Holmgren, Holmgren, Scoot Henderson –, Thompson, Ausar Organizations: CNN, National Basketball Association, NBA, TNT, ESPN, ABC, NBA TV, ESPN Radio, Portland Trail Blazers, Miami Heat, Milwaukee Bucks, Milwaukee, Trail Blazers, Boston Celtics, Lakers, Bucks, Milwaukee’s, Los Angeles Lakers, , Oklahoma City Thunder, Eastern Conference, Celtics, New York Knicks, Philadelphia 76ers, Denver Nuggets, Denver, Jokić, Nuggets, Memphis Grizzlies, Phoenix Suns, Los Angeles Clippers, Golden State Warriors, Minnesota Timberwolves, New Orleans Pelicans, Dallas Mavericks, Suns, Grizzlies, Clippers, Pelicans, Warriors, Timberwolves, Mavericks, San Antonio Spurs, Spurs ’, Heat, Oklahoma City, Thunder, Summer League, Spurs, Houston Rockets, Detroit Pistons Locations: Las Vegas, Oregon, Boston, East, Sacramento Kings, Alamo City
First, Jewish donors probably can’t win the identity politics game. But this strategy also has inherent limits, insofar as the free speech protected by campus administrators is only as diverse as the people who are speaking. Which brings us to the second point for would-be reshapers of the university: If you can’t influence faculty hiring and tenure, you may be wasting your money. Will the University of Pennsylvania miss the collection of major donors who’ve denounced the school in the past week? But not with the goal of using such student groups as a means of conflict with the administration or the faculty.
Persons: Jason Willick, specter, Willick, you’re, Donald Trump, there’s, Bernie, Sanders, they’re, who’ve, Leland Stanford ”, Rather, Michael Brendan Dougherty, Chris Caldwell, Anthony Grafton, Anthony Lane, Arthur Brooks, George Orwell, Zvi Mowshowitz, Keith Phipps, Martin Scorsese’s “, Foucault, — Maxi, Organizations: The Washington Post, Cornell, University of Pennsylvania, Big, Hillel, Penn, Locations: The Washington, State, Israel, tokenism, Harvard, Poland, Foucault’s
REUTERS/Dado Ruvic/Illustration/File photo Acquire Licensing RightsOct 3 (Reuters) - The U.S. Food and Drug Administration staff reviewers said on Tuesday Amgen's (AMGN.O) late-stage study might not be sufficient to confirm the effectiveness for its lung cancer drug, as the firm pursues a traditional nod for the treatment. Amgen's drug was granted accelerated approval by the U.S. FDA in 2021 for advanced lung cancer patients with KRAS mutations whose disease has worsened after treatment with chemotherapy or other medicines. The U.S. health regulator grants the so-called accelerated approval based on data that show therapies are likely to work, and requires confirmatory trials later to give them traditional approval. Data from the study showed Lumakras reduced the risk of disease progression in patients with advanced lung cancer by 34%, compared with chemotherapy in a clinical trial. The agency is expected to make a decision on traditional approval for the drug by Dec. 24.
Persons: Dado Ruvic, Amgen's, William Blair, Matt Phipps, Lumakras, Bhanvi Satija, Shounak Dasgupta, Sherry Jacob, Phillips Organizations: REUTERS, U.S . Food, Drug Administration, U.S, FDA, Thomson Locations: U.S, Bengaluru
That includes the agency's examination of Pfizer 's proposed $43 billion purchase of cancer drug developer Seagen . Some also speculated that the restrictions imposed on Amgen as part of the settlement could have implications for other deals. The FTC's lawsuit against Amgen in May was the agency's first legal challenge to a pharmaceutical buyout in 14 years. The settlement agreement prohibits Amgen from bundling any of its products with two of Horizon's blockbuster drugs, among other restrictions. Still, some analysts said the restrictions suggest the FTC could apply similar rules to other buyouts in the future.
Persons: Amgen, William Blair, Matt Phipps, Robyn Karnauskas, baring, Nathan Ray, West, Biden, Evan Seigerman Organizations: Federal Trade Commission, Horizon Therapeutics, Pfizer, FTC, West Monroe, Amgen, Pharmaceutical, Pharma, BMO Capital Locations: Amgen
The judge had ruled that Williams failed to claim that he would not have been fired but for his race. Tech Mahindra's U.S. subsidiary has more than 5,000 employees and 90% of them are South Asian, according to filings in the case. The case is Williams v. Tech Mahindra Americans Inc, 3rd U.S. Circuit Court of Appeals, No. For Williams: Mark Hammervold of Kotchen & LowFor Tech Mahindra: Kenneth Gage of Paul HastingsOur Standards: The Thomson Reuters Trust Principles.
Persons: Lee Williams, Williams, Brian Martinotti, Martinotti, Peter Phipps, Joseph Greenaway, Cheryl Krause, Mark Hammervold, Kenneth Gage, Paul Hastings Organizations: South, IT, Tech Mahindra Ltd's, U.S, Circuit, Appeals, Tech Mahindra, Lawyers, Civil, Tech Mahindra's, District, . Tech Mahindra Americans Inc, Low, Paul Hastings Our, Thomson Locations: New Jersey, North Dakota, Newark
Developments in cancer research will be in the spotlight as the American Society of Clinical Oncology hosts the world's biggest cancer research conference in Chicago, starting Thursday. The pair has already has won regulatory approval for Enhertu for metastatic HER2-low breast cancer, but the companies are also studying its use in a variety other HER2 tumors in breast cancers. Lilly's drug, Verzenio, is used in high-risk patients with HR-positive HER2-negative breast cancer that is more likely to reoccur and has already breached the patient's lymph nodes. In a research note earlier this month, Guggenheim analyst Seamus Fernandez said Kisqali is already taking market share from Pfizer's Ibrance in metastatic breast cancer. Merck's Keytruda is also being watched for what benefits it could offer early-stage lung cancer patients .
High jump pioneer and icon Fosbury dies at 76
  + stars: | 2023-03-13 | by ( ) www.reuters.com   time to read: +3 min
March 13 (Reuters) - Olympic high jump champion Dick Fosbury, who revolutionised the event with a radically different jumping technique that was eventually named after him, died on Sunday aged 76, his agent Ray Schulte said on Monday. The straddle or scissor jump were common techniques in the high jump. "With his groundbreaking "Fosbury Flop" technique, Dick Fosbury not only won Olympic gold at Mexico City 1968 but also revolutionized the high jump. "I am deeply saddened by the passing of Dick Fosbury, a true legend and pioneer in the world of track and field. Dick's innovative technique of the 'Fosbury Flop' revolutionized the high jump event and forever changed the sport," said Max Siegel, CEO of USA Track & Field.
Authorities had no physical evidence or weapon that linked Phipps to the shooting, and the then 22-year-old had no criminal record. Through her research Kubrin has found bias against rap music and artists, she said, adding that much of that bias is racialized. That means using lyrics from rap music, a historically Black genre, can infect jurors with anti-Black racism regardless of whether the defendant himself is Black, she said. Defending the practiceFulton County prosecutor Fani Willis, whose office is trying the case against Young Thug and other YSL members, has defended using music lyrics in trials. Gavin Newsom signed the Decriminalizing Artistic Expression Act, which made it the first state to restrict the use of rap lyrics as evidence in state court.
Investors looking for cover this year would have done well if they sought a safe haven in large-cap pharmaceutical stocks, a trend that is likely to continue into 2023. The Inflation Reduction Act provided some clarity around drug pricing that should help health-care stocks. The average price target, according to FactSet, is $62, or nearly 40% above the stock's closing price on Tuesday. Gene therapies in focus Investors will be closely watching the progress of several gene therapies, according to Phipps. "Yes, these are expensive therapies," Phipps said.
Amgen gains several approved drugs through the deal, a bulwark against rising competition for its blockbuster arthritis drug, Enbrel, from newer treatments. Sales of Amgen's Enbrel tumbled 14% in the latest reported quarter to $1.1 billion, extending a run of downbeat performances. The Horizon bid follows Amgen's $3.7 billion deal in August for rare blood vessel inflammation treatment maker ChemoCentryx Inc . The offer values Horizon at $27.8 billion on a fully diluted basis, according to the company, which includes ordinary shares to be vested. Based on Reuters calculations, it values Horizon at about $26 billion and gives Horizon a $28.3 billion valuation, including debt.
More than 11% of Americans have diabetes, which occurs when the pancreas does not produce enough insulin to regulate blood sugar levels. As a nutritionist who has been living with type 1 diabetes for more than 30 years, I've found that having diabetes doesn't mean you have to completely stop eating what you enjoy. Managing blood sugar is often more about making small food swaps, or adding, rather than eliminating, certain foods. Protein, fat and fiber all moderate how quickly food is digested, which is helpful in balancing blood sugar levels. Here are the foods I eat — and the foods I try to cut back on — to help manage my diabetes:
The trial between Twitter and Elon Musk will begin on October 17 at the Delaware Chancery Court. The Delaware judge hearing Twitter's case vs. Elon Musk listened incredulously as Musk's lawyers asked her to postpone the trial. The DecoPac deal, like many acquisitions, had a clause called "specific performance," which allows the courts to force the deal to close. It didn't take long for McCormick's life at the Chancery Court to get interestingElon Musk agreed to buy Twitter in April 2022. And Twitter then sued Musk for specific performance in Delaware Chancery Court later that month.
Acest lucru permite oamenilor de știință să evite utilizarea datelor epidemiologice și serologice, care vin cu limitările testării. Comparând noile estimări cu cazurile oficiale confirmate, echipa a reușit să prezică rata de infecție „adevărată” pentru fiecare țară. Conform rezultatelor acestora, la sfârșitul lunii august, rata infecției populației a fost, în medie, de șase ori mai mare decât cazurile raportate, scrie descopera.ro. În general, din martie, țările din întreaga lume și-au îmbunătățit capacitățile de testare COVID-19, educând publicul cu privire la simptome și oferind modalități din ce în ce mai precise de detectare și urmărire a infecției. Chiar și în Australia, care are unul dintre cele mai bune niveluri de detectare dintre toate cele 15 țări studiate, cercetătorii spun că rata infecției ar putea fi în continuare de aproape cinci ori mai mare decât cele raportate.
Persons: Steven Phipps Organizations: Ikigai Locations: Australia, Ikigai Research
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