Oftentimes, commencement speakers conclude their speeches with something to the effect of, "now go out and change the world." Taking smart risks can ultimately lead to revolutionary ideas, says John Crowley, executive chairman of Amicus Therapeutics, a biotechnology company. But if your ultimate career goal is to change the world, you may be setting yourself up for disappointment. "Very few people have changed the world," Crowley tells CNBC Make It. Crowley says that smart risk-takers avoid setting lofty, broad goals, opting instead for clear, tangible goals.

---

Persons: John Crowley, Crowley, they've, —, Bill Gates, Paul Allen, Steve Jobs, Steve Wozniak, Kelly Evans Organizations: Amicus Therapeutics, CNBC, Novazyme Pharmaceuticals, Genzyme Corporation, Microsoft, Apple