Newcastle won 3-0 at Old Trafford and Howe was pleased to see a heavily rotated starting lineup repay his faith in them.
"It was great to be able to give everyone an opportunity and I thought they responded magnificently," Howe told reporters ahead of Saturday's game against Arsenal.
A stern test awaits, however, with Newcastle welcoming Mikel Arteta's Arsenal to St James' Park.
Since 2010, Newcastle have beaten Arsenal only twice in 24 matches in all competitions, losing 19 times.
They are unbeaten, it is a really big test of our credentials," Howe said.
Persons:
Eddie Howe, Howe, Mikel Arteta's, Matt Targett, Sandro Tonali, We've, Sandro, Rohith Nair, Ed Osmond
Organizations:
Newcastle United's League, Manchester United, Premier League, Arsenal, Newcastle, Old, Mikel Arteta's Arsenal, James, Tottenham Hotspur, Thomson
Locations:
Old Trafford, Bengaluru