Reilly Smith, Alec Martinez and Chandler Stephenson scored for the Golden Knights (51-22-9, 111 points), who closed the regular season with an eight-game points streak (5-0-3).
Liam O'Brien led the Coyotes with a pair of goals and Nick Schmaltz and added a goal and an assist.
The Stars, who are looking to win a division title for the first time since the 2015-16 campaign, are atop the division.
The Bruins set NHL records for most wins and most points in a single season.
Tage Thompson scored his 47th goal of the season for Buffalo, which improved to 8-2-1 over its last 11 games.