Lugo hasn't started a major league game in the regular season since 2020 and has just 38 career starts.
Trent Grisham went 2-for-3 and Aaron Brooks got the win for the Padres, as they held the White Sox to four hits.
Athletics 12, Diamondbacks 7Kevin Smith went 2-for-3 with three RBIs and Jace Peterson drove in two as host Oakland beat Arizona in Mesa.
McLain went 2-for-2.
Brewers 7, Dodgers 4Garrett Mitchell hit two home runs and had four RBIs to lead host Milwaukee past Los Angeles in Phoenix.