President Joe Biden's administration has said it plans to appeal the 5th Circuit's decision as well.
The 5th Circuit's decision partially sided with the anti-abortion groups and doctors who challenged mifepristone.
In April, the Supreme Court granted emergency requests by the Justice Department and the pill's manufacturer Danco Laboratories to put on hold Kacsmaryk's order while litigation continued.
Mifepristone is taken with another drug called misoprostol to perform medication abortion, which accounts for more than half of all U.S. abortions.
Since last year's Supreme Court decision, at least 14 U.S. states have put in place outright abortion bans while many others prohibit abortion after a certain length of pregnancy.
Persons:
Evelyn Hockstein, mifepristone, Joe Biden's, Jessica Ellsworth, Circuit upended, Matthew Kacsmaryk, Roe, Wade, Andrew Chung, Will Dunham
Organizations:
Alamo Women's, REUTERS, U.S, Supreme, Danco Laboratories, New, Circuit, U.S . Food, Drug Administration, FDA, Justice Department, mifepristone, Republican, Alliance for Hippocratic Medicine, Defending, Thomson
Locations:
Carbondale , Illinois, U.S, New Orleans, Amarillo , Texas, New York