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Read previewScientists have reported a major breakthrough in our understanding of inflammatory bowel disorder. The underlying pathway for inflammatory bowel disease had previously been poorly understood, making it difficult to find treatments. They dialed up the ETS2 in macrophages in the lab, and sure enough, inflammation similar to that seen in patients with inflammatory bowel disease. Conditions like inflammatory bowel disease and Crohn's disease affect almost 5% of the population, and there is currently no cure. AdvertisementUnderstanding the potential biological pathways that underlie these diseases could also help researchers fight inflammatory conditions like autoimmune disorders, too.
Persons: , Francis Crick, Dr James Lee, gastroenterologist, Lee, we're, Christina Stankey Organizations: Service, University College London, Business, Royal Free Hospital, Guardian, Francis, Francis Crick Institute Locations: IBD, Nature
Washington CNN —Donald Trump hasn’t shown much interest in reaching out to Republicans who hate him. Or, he argued, “they’re likely to stay home.”Hutchinson told CNN he won’t stay home himself, but he won’t vote for Biden or Trump. “This swath of Republican strategist types are literally begging the Biden campaign to give them a reason to support him,” a former House Republican leadership aide told CNN. “You can hold your nose and vote for Biden and not be in public screaming about it. But Purcell has also not yet heard from the Biden campaign this time.
Persons: Washington CNN — Donald Trump hasn’t, Joe Biden, Adam Kinzinger’s, Austin Weatherford, Nikki Haley, Haley, Biden, Anita Dunn, Cassidy Hutchinson, Anthony Scaramucci, Liz Cheney, John Kasich, Trump, Cindy McCain, shouldn’t, , , Jen O’Malley Dillon, they’ve, mattering, Denver Riggleman, Kinzinger, Paul Ryan, Chris Christie, Mike Pence, Mark Cuban, doesn’t, he’s, Joe, , Larry Hogan, I’m, ’ ” Hogan, ” Hogan, they’re, Carolina Sen, Lindsey Graham, it’s Biden, Asa Hutchinson, Daisy Bates, Hutchinson, “ You’ve, you’re, ” Hutchinson, “ they’re, won’t, Indiana Sen, Todd Young –, Biden –, ” Young, Young, Christine Todd Whitman, George W, Bush, ” Whitman, Whitman, Joe Walsh, don’t, MAGA, Claudine Schneider, Schneider, Geoff Duncan, Donald Trump, ’ ” Duncan, ” Duncan, “ ‘ Will, Biden George H.W, Hillary Clinton, “ he’s, He’s, Howard Stern, “ Where’s Jeb Bush, Where’s George Bush, ’ ” Biden, Jeb Bush, Hogan, Kristopher Purcell, Purcell Organizations: Washington CNN, Republican, White, Trump, Democratic, Ohio Gov, CNN, Republicans, Trump Republican, Virginia Rep, Denver, Trump Republicans, Former New Jersey Gov, Tech, Biden, Senate, South, Capitol, New, Environmental Protection Agency, Independents, Illinois, Republican Party, MAGA Republicans, Congress, Trump ., Bush Republicans, Maryland Senate Locations: Biden’s, Wilmington, Israel, Ukraine, Former, Dallas, Maryland, Baltimore, York, South Carolina, Carolina, Arkansas, New Jersey, Trump, Rhode Island, Georgia
The result is that class A units account for more than half the apartment market, compared with one-third in the early 2000s, according to Moody's Analytics. High-end apartments that offer amenities up the wazoo — and rent breaks, to boot — represent a tantalizing alternative to the for-sale market right now. But as with all good things, the golden age for America's wealthy renters must also come to an end. Nations told me she still hoped to buy a home one day. "I know how challenging it is to rent in Nashville, especially on your own," Nations told me.
Persons: Emily Nations, she's, Nicole Bachaud, Rich, Joel Sanders, Sanders, Doug Ressler, David Brasington, Ressler, they're, Organizations: Trinity, cabana, Nations, Analytics, University of Cincinnati, Census Locations: Nashville, downtown, Nations, New York, Salt Lake City, Atlanta, America, Houston, Austin, Phoenix, Charlotte, North Carolina, Raleigh , North Carolina, Tampa , Florida
Last season, the Gunners were edged out in the Premier League title race by five points. “I think we should be very proud of what we’ve done throughout this season, both in European competition and the Premier League. Champions League football has returned to the Emirates and so, too, has silverware. Catherine Ivill/ReutersYet it is the holy grail of the Premier League that he, the players, and the fans still so greatly crave. The former hinted after his latest league accomplishment that his stay in the Premier League is more likely than not to be drawing to a close.
Persons: Mikel Arteta, Pep, “ I’m, ” Arteta, Amanda Davies, , Arteta, Catherine Ivill, , Guardiola, Jason Cairnduff, he’d, that’s, We’ve, Glyn Kirk, Declan Rice, Kai Havertz, I’m Organizations: Italy CNN, Arsenal, Manchester City, Gunners, Premier League, CNN, Globe Soccer, Arteta, North London, Champions League, Emirates, City, Sky Blues, Barcelona’s, Guardiola, Getty Images, West Ham United, Chelsea, Ajax, it’s Locations: Sardinia, Italy, North, Catalunya, North London, Manchester, AFP, London
He’s won six Ligue 1 titles, three French Cups, two League Cups and a record five Player of the Year awards. The closest Mbappé came to winning the Champions League was reaching the final in 2020. Even if Mbappé was to lift one more trophy, can his time in Paris be considered a success if he didn’t achieve the club’s ultimate goal? “He’s their all-time top scorer, he’s won the league’s Player of the Year award five times in a row. “What’s interesting is he’s not necessarily captured the hearts of fans, especially in the way he’s left the club.
Persons: Kylian Mbappé, Germain, Nasser Al, Khelaifi, Zlatan Ibrahimović, Lionel Messi, Neymar, He’s, Julian Finney, ” Mbappé, Mbappé, , Raphaël Jucobin, , ” Jucobin, he’s, Michael Regan, Real, , Frenchman, Jucobin, “ He’s, Marco, Verratti, Thomas Meunier, L’Equipe, ‘ Kyks, Neymar Jr, Aurelien Meunier, Messi, Vinícius Jr, Jude Bellingham, relishes, It’s Organizations: CNN, Paris Saint, PSG, Monaco, Ligue, Champions League, Qatari, Bayern Munich, League, UEFA, French, Lyon, Real Madrid, FIFA, Mbappé, Independent, Al, Parc des Princes, Toulouse, Qatar, Ouest, European, , Los Blancos, French national Locations: Paris, France, , Saudi, Hilal, Parc des, Ouest France, ” Real Madrid, Real
JPMorgan is testing a generative AI "copilot" within its private bank, a move that is already saving advisors a couple of hours a day. AdvertisementHow Donnelly's team drives innovation in the private bankJPMorgan's private bank caters to clients with at least $10 million in assets. The unit's $974 billion in assets are managed by just over 3,500 client advisors. When the CEO of JPM's private bank tapped an advisor with little to no technical experience to lead digital product for his division, it was intentional. He didn't "want the individuals that are deciding the advisor experience and client experience not to sit amongst the front-office users," she said.
Persons: Karen Donnelly, Donnelly, Morgan Stanley, Mary Erdoes, Dan Pinto's, JPMorgan's, She's, aren't, David Frame, , Donnelly doesn't, gunning Organizations: Service, JPMorgan, Business, Advisors, ChatGPT
JPMorgan is testing a generative AI "copilot" within its private bank, a move that is already saving advisors a couple of hours a day. AdvertisementHow Donnelly's team drives innovation in the private bankJPMorgan's private bank caters to clients with at least $10 million in assets. The unit's $974 billion in assets are managed by just over 3,500 client advisors. When the CEO of JPM's private bank tapped an advisor with little to no technical experience to lead digital product for his division, it was intentional. He didn't "want the individuals that are deciding the advisor experience and client experience not to sit amongst the front-office users," she said.
Persons: Karen Donnelly, Donnelly, Morgan Stanley, Mary Erdoes, Dan Pinto's, JPMorgan's, She's, aren't, David Frame, , Donnelly doesn't, gunning Organizations: Service, JPMorgan, Business, Advisors, ChatGPT
The images will then be used to build an inventory of the archaeological discoveries on the seabed. But it has also sparked a multi-billion dollar legal battle. Colombia maintains that it first discovered the San José in 2015 with help from international scientists. SSA has launched a legal battle against the Colombian government in the Permanent Court of Arbitration, claiming it is entitled to approximately $10 billion – half the estimated value of the shipwreck’s treasure. The loss of the San José and its cargo was said to have caused financial hardships to merchants throughout Europe and the New World, according to reports released by SSA.
Persons: , Juan David Correa Organizations: CNN, Colombian Institute of Anthropology, Wednesday, San, San Jose Galleon, SSA Locations: Colombia, Spanish, Caribbean, Cartegena, Colombian, Potosi , Peru, Panama, Cartagena, San Jose, José, Europe
By Ganesh Bukka, Vice President & Global Head, Industry 4.0, Hitachi Digital ServicesData is supposed to unlock operational efficiency and productivity. OT and IT integration can enable business agility, optimize operations, help businesses hone their competitive edge, and inform decision-making so they can quickly seize emerging business opportunities. Data integration supports intelligent decision-making, which in turn supports business continuityThe real-world perspective is essential because this is not a theoretical discussion. Realize OT and IT integration with an industry-experienced partnerAchieving that level of performance requires the intelligent integration of OT and IT. Learn more about how Hitachi Digital Services partners with companies to integrate OT and IT and empower informed decision-making.
Persons: Ganesh Bukka Organizations: Global, Industry, Hitachi Digital Services, Hitachi, Insider Studios
The dredging project is expected to be completed in Fall 2025, making the Port of Virginia the deepest and widest harbor on the East Coast. "Ultra-large container vessels have challenged every port," said Stephen Edwards, CEO of the Port of Virginia. Edwards said the port was able to quickly absorb Baltimore freight because of the ocean carrier service overlap in calling on the Port of Virginia, Baltimore and Port of New York/New Jersey. In January, the port became the first East Coast port to power all its terminals with 100% clean energy, eight years ahead of the 2032 target it set for that goal. The expansion will increase the fleet at NIT to 152 electric stacking cranes, seven electric rail cranes, and 31 electric ship-to-shore cranes.
Persons: Lori Ann LaRocco, Stephen Edwards, " Edwards, Edwards, It's, Good Hope, D'Andrae Larry, Larry, Jones, monopiles, Monopiles Organizations: NIT, CNBC, U.S ., Commonwealth, Walmart, Maersk, Port, Baltimore, Rail, Norfolk International, Uber, Virginia Department of Transportation, Dominion Energy, Rappahannock Electric Cooperative, ClearView Energy Partners, of Ocean Energy, U.S, District of Columbia, Dominion Locations: Port of Virginia, Port, Virginia, U.S . East Coast, Norfolk, Coast, of Virginia, East Coast, U.S, Delaware, South, Southeast Asia, Northeast Asia, India, Red, Suez, Good, Baltimore, Port of Baltimore, Port of New York, New Jersey, of Virginia's, Commonwealth, Norfolk , Virginia, East, Virginia Beach
AdvertisementSo, Business Insider asked some style experts — and a finance bro — which brands and styles those on Wall Street should check out for their summer workwear. Men's fashion consultant Reginald Ferguson told BI that he wants his clients to remain "modern, yet classic" in their daily attire. Charles Tyrwhitt; Peter MillarPeter Millar and Charles Tyrwhitt were two brands suggested to BI by an early-career investment banker who asked to remain anonymous to protect his career. It's a "luxury golf brand that was smart to expand its line for its client to wear other garments while not on the course," Ferguson told BI. Kiton, another high-end brand with origins in Italy, is "the grail for the partner of the firm," Ferguson told BI.
Persons: , Goldman Sachs, Mark Zuckerberg, Jeff Bezos —, Lauren Sanchez —, bro, Reginald Ferguson, Peter Millar, Charles Tyrwhitt, Peter Millar Peter Millar, Ferguson, nodded, Nicole Pollard Bayme, Bayme, Billionaire Bill Gates, Larry Ellison, Richard Mille Organizations: Service, bros, JPMorgan, Citigroup, Business, BI, LA, Casio, Getty, Billionaire Locations: Silicon, British, Italy
That watch was the “most beautiful thing I’d ever seen,” Stallone said in a video released by Sotheby’s, and sparked a decades-long love of watch collecting. And now, the Hollywood star is auctioning 11 watches from his personal collection at a Sotheby’s sale in New York on June 5. Among the items is the rare Patek Philippe Grandmaster Chime, which is expected to fetch as much as $5 million, as well as watches he wore in some of his films. The Grandmaster Chime is the most complicated ever Patek Philippe watch. Another Patek Philippe watch, this one from its Nautilus family, is expected to sell for up to $400,000.
Persons: Sylvester Stallone, Gregg Allman, Allman, ” Stallone, Sotheby’s, Philippe Grandmaster, Philippe, , Phillipe, Stallone, Audemars Piguet, Cartier, Sotheby's Organizations: CNN, Hollywood, Rolex Locations: New York
Shruti Gandhi has a simple rule for meeting founders: She only takes the meeting if she wants to invest. Being the solo general partner of her firm, the early-stage outfit Array Ventures, also means she can get deals done quickly. Over the past five years, she's returned most of her maiden $7 million fund to limited partners at a net multiple of almost four. For founders, by foundersThe founders Gandhi has backed like working with her because of her technical chops and hands-on approach. We will back you if you raise a fund,'" Gandhi said.
Persons: Shruti Gandhi, Gandhi, Nikhil Teja Kolli, Kolli, she's, wasn't, Dumbledore, Harry Potter, Champ Bennett, Zimperium's Zuk Avraham, Mehul Nariyawala, Google —, Doktor Gurson, Gurson Organizations: Ventures, Business, PayPal, IBM, Columbia University, True Ventures, Samsung, Google, University of Chicago Booth School of Business, Rad Locations: India, Poughkeepsie , New York, She's
The past few years have been tough for edtech companies. In recent months, multiple edtech startups have raised fresh funding rounds while specifically touting AI as a core part of their business model. These deals could signal that AI is ushering in a new era for edtech companies, and VCs who invest in the space are excited about the renaissance. And Ednition, also one of Donnelly's portfolio companies, provides an infrastructure-as-a-service platform for other edtech companies to improve the data that goes into their AI models. That's why it's so important to invest in ed-tech AI startups that help people rethink how they interact with technology and learn new skills necessary to successfully enter the workforce, he said.
Persons: PitchBook, VCs, Brian Dixon, Dixon, we've, Numerade, Kapoor, Katelyn Donnelly, she's, I've, you'll, Donnelly, Avalance, OpenAI, we're, ChatGPT, Ryan Craig, Craig, edtech Organizations: Business, Labs, Kapor, Partners, Chingona Ventures, TechCrunch, Kapoor Capital, Lirvana Labs, Odyssey Education, University Ventures, ACT Locations: VCs, edtech
The labor market has continued to be strong, dampening any urgency the Fed might have to cut rates. AdvertisementThe Fed's decision to hold rates steady prompted some pushback from Democratic lawmakers who are worried that continued high rates will hurt Americans. "The Fed must remember its dual mandate and avoid keeping these rates too high for too long," Boyle said. And he won't risk easing up on the Fed's restrictive policy too early. Advertisement"We believe it is restrictive, and we believe over time it will be sufficiently restrictive," Powell said.
Persons: , Jerome Powell, Powell, We've, we're, Julia Pollak, Brendan Boyle, Boyle, he's Organizations: Service, Federal, Market Committee, Business, Fed, Democratic, Rep
The Federal Reserve is expected to once again hold interest rates steady on Wednesday. Some predictions also do not forecast any interest rate cuts until the second half of the year. AdvertisementIt's probably still not time for the nation's central bank to cut interest rates just yet. AdvertisementGiven that inflation is still above the Fed's 2% target, it's looking like rate cuts might not come until the second half of 2024. "Inflation has continued to run hot and there is no compelling need for the Fed to cut interest rates until they're comfortable with where inflation is headed."
Persons: Powell, , It's, Julia Pollak, Jerome Powell, Gregory Daco, Greg McBride Organizations: Federal, Service, Fed Locations: Washington
Now the California-based startup is attempting to make asteroid mining a reality. That makes AstroForge the only company with a refinery that can turn M-type asteroids into PGMs in space, he adds. Some in the scientific community are skeptical that the private sector will be able to afford asteroid mining. Its all-or-nothing, lower-cost approach may help push asteroid mining closer to reality. “I hope if nothing else,” Gialich says, “we’re known as a space company that went for it.”
Persons: Matt Gialich, Gialich, Jose Acain, , , we’re, “ We’re, AstroForge, Edward Carreon, “ that’s, , Dan Britt, REx, James Cameron, Larry Page, Britt, “ I’m, ” Gialich, NASA's, Aubrey Gemignani, ” Britt, AstroForge’s Organizations: CNN, Virgin, SpaceX, NASA, Companies, Apple, Center, University of Central, JAXA, United, United Arab Emirates ’ Space Agency, UAE Space Agency, AP NASA, Planetary Resources, Titanic, Google, NASA's Kennedy Space Center, Getty Locations: California, University of Central Florida, China, United Arab, United Arab Emirates, Utah, Los Angeles, Florida
"There's a lot going on in the space," said Judy Kimball, a senior director of investor marketing at Yipit. Initial Data Offering launched last December, and its user base has grown rapidly, according to Ober. The site is simple — it's a place where data vendors can share new products, and data buyers can get in touch with sellers on items that interest them. Now, his side hustle is growing faster than he could have imagined, and he hopes to expand beyond the typical hedge fund crowd. Because this isn't Ober's day job, the build-out can be less about revenue and more about growing the community.
Persons: Carlyle, aren't, Judy Kimball, It's, Lowenstein Sandler, Matt Ober, Ober, Kimball, Yipit Organizations: Business, IDO Locations: San Diego, Ober
Inflation came in hotter than expected in March
  + stars: | 2024-04-10 | by ( Madison Hoff | ) www.businessinsider.com   time to read: +2 min
March's year-over-year increase was forecasted to be a higher rate than February's rate. The forecast for March's year-over-year increase in the CPI was 3.4%, a higher rate than the 3.2% increase or the 3.1% increase in February or January respectively. The rate came in above the forecast and was higher than February's year-over-year change. CPI increased 0.4% in March from the preceding month — same as the 0.4% surge in February. AdvertisementAverage hourly earnings increased 4.1% year over year to $34.69 an hour in March, which fell short of the 4.3% year-over-year increase in February.
Persons: , That's, Julia Pollak, Pollak Organizations: Consumer, Service, Bureau of Labor Statistics, Business Locations: March's, That's
Using a salt substitute when cooking was linked with a lower risk of dying early from any cause or from cardiovascular disease in a new study published Monday in the journal Annals of Internal Medicine. “Previous synthesis tended to focus on short-term outcomes, lasting only two weeks.”Using a salt substitute could lower your risk of dying early, according to new research. The trials compared the use of common salt — made of about 100% sodium chloride, occasionally with added iodine — with using a salt substitute comprised of 25% to 30% potassium chloride and 60% to 75% sodium chloride. “If it’s sodium chloride or potassium chloride or magnesium chloride, it’s all salt. “It’s also important to remember that reducing sodium intake is just one way to reduce cardiovascular risk without medication,” Albarqouni said.
Persons: , Loai, , ” Albarqouni, Albarqouni, Andrew Freeman, ” Freeman, wasn’t, Freeman, It’s Organizations: CNN, Internal Medicine, Institute, Bond University, Jewish Health Locations: Australia, China, United Kingdom, Taiwan, Peru, Netherlands, Norway, North America, Denver
Determining the best predictors of stock-market returns is like seeking the Holy Grail for investors. They also allowed the algorithm to come up with its own ratios in an attempt to determine whether there are better indicators of stock-market performance. Examples of variables included sales, market value, and cost of goods. The data points were then scaled using ratios to correlate a company's sales revenue to other variables, such as its size. Robbins noted that traditionally, academics begin with a theory for why certain company fundamentals could be good predictors of stock market returns before testing them.
Persons: Alejandro Lopez, Lopez, Andrew Y . Chen, Tom Zimmermann, Michael Robbins, Lira, ChatGPT, Robbins, It's Organizations: Lira, University of Florida, University of Cologne, Institutional, Investors, New York Stock Exchange, American Stock Exchange, Nasdaq, Lopez
And he’s got some constraints,” Woods’ friend Notah Begay III told a conference call on Wednesday, according to USA Today. According to Sports Illustrated, Woods played Augusta National last weekend with friend and PGA Tour peer Justin Thomas and club chairman Fred Ridley. Woods made his first appearance on the PGA Tour this year in February at the Genesis Invitational – an event he hosts. After admitting he had been suffering from back spasms during the first round, Woods withdrew during the second round, saying he was dealing with influenza. According to the PGA Tour, Woods has made the cut in 23 consecutive starts at Augusta, a record he shares with Fred Couples and Gary Player.
Persons: Woods, “ He’s, he’s, ” Woods, Notah Begay, , , Begay, Justin Thomas, Fred Ridley, ” Begay, That’s, Jack Nicklaus, Fred Couples, Gary Player Organizations: CNN, USA, Sports, Augusta National, Stanford University, PGA Locations: Augusta
But his career and trajectory have always been defined by global experience, exposure and a passion for embracing other cultures and cuisines. Back in 2006, Australian Chef Shane Osborn of Hong Kong’s acclaimed Arcane hired Calvert to work at his two Michelin-starred Pied à Terre restaurant in London. The culinary Holy Grail of Paris followed, with a stint at Epicure, which like Per Se is also a three Michelin-starred restaurant. His global culinary journey continued with a move to Hong Kong and the contemporary Parisian bistro Belon, where he earned the restaurant a Michelin star and reached fourth place on the list of Asia’s 50 Best Restaurants. Calvert is happy to modestly take the considerable accolade of the best restaurant in Asia with a pinch of salt, as it were.
Persons: Daniel Calvert, , , It’s, Shane Osborn, Hong Kong’s, Arcane, Calvert, who’ve, ” Osborn, Daniel Calvert's, Chef Thomas Keller’s, Paris, “ I’ve, ” Calvert, Hong, André Fu, morel, SÉZANNE Calvert, Ashley Caley, shima, botan ebi, there’s, sommelier Nobuhide Otsuka, “ I’m, ” Chris Dwyer Organizations: CNN, Champions League, Michelin, Sézanne Locations: Sézanne, “ Tokyo, Marunouchi, Tokyo, London, British, London , New York, Paris, Hong Kong, New York, Epicure, France’s Champagne, Hokkaido, France’s Jura, Yamaguchi Prefecture, morel, bouillon, Asia, @chrismdwyer, Instagram
Often referred to as the holy grail of climate solutions clean energy, fusion has the potential to provide limitless energy without planet-warming carbon pollution. KSTAR’s work “will be of great help to secure the predicted performance in ITER operation in time and to advance the commercialization of fusion energy,” Si-Woo Yoon said. This announcement adds to a number of other nuclear fusion breakthroughs. But commercializing nuclear fusion still remains a long way off as scientists work to solve fiendish engineering and scientific difficulties. Nuclear fusion “is not ready yet and therefore it can’t help us with the climate crisis now,” said Aneeqa Khan, research fellow in nuclear fusion at the University of Manchester in the UK.
Persons: Woo Yoon, , Aneeqa Khan, Angela Dewan Organizations: CNN — Scientists, KSTAR Research, Korean Institute of Fusion Energy, CNN, International, Reactor, Lawrence Livermore, Oxford, University of Manchester Locations: South Korea, France, United States
A new GLP-1 drug, pemvidutide, helped patients lose fat while guarding muscle, like exercise does. That's impressive when you compare it to existing GLP-1 drugs like Ozempic and Wegovy (semaglutide), or Mounjaro and Zepbound (tirzepatide). This is why doctors recommend patients on weight loss drugs do some strength training in tandem with their medication. Pemvidutide, like tirzepatide is a two-part drug that combines a GLP-1 drug with another drug in a single shot. "There is a growing appreciation that the quality of weight loss is as important as the quantity of weight loss," Scott Harris, Altimmune's chief medical officer, said in a release.
Persons: Drugmakers Eli Lilly, , Drugmaker Altimmune, Altimmune, Scott Harris, Eli Lilly, FierceBiotech, Versanis Organizations: Novo Nordisk, Service Locations: Altimmune, GLP
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