Political figures, including Prime Minister Elisabeth Borne and former presidents Francois Hollande and Nicolas Sarkozy, headed the march, holding a banner with the slogan "For the Republic, against antisemitism".
They led several renditions of the French national anthem.
Left-wing lawmakers have joined pro-Palestinian protests in recent weeks, including a march in Paris on Saturday.
Protests against antisemitism also took place in other French cities on Sunday, including in Marseille where some 7,000 people turned out according to a police estimate.
Elsewhere in Europe, concern is running high over antisemitism and other forms of extremism being whipped up.
Persons:
Yael Braun, Elisabeth Borne, Gerard Larcher, France Francois Hollande, Nicolas Sarkozy, Francois Hollande, Emmanuel Macron, Macron, Benjamin Netanyahu, Gus Trompiz, Tangi Salaun, Lucien Libert, Marc Leras, Barbara Lewis
Organizations:
National, . Police, ., Thomson
Locations:
France, PARIS, Paris, Gaza, Israel, Republic, Sunday's, Marseille, Europe, Britain