The match at the San Siro will be the first time since 1962 that the Milan sides meet while top of the table.
But this Milan side are a different proposition from the team who put up such a disappointing defence of their league title last season.
Preparations for the derby will mostly come down to the last few days with most of their starting players returning from international duty.
Milan have a concern over Giroud after he went off injured in France's win over Ireland last week but are hopeful he can recover.
Jose Mourinho's AS Roma, with just one point from three games, will try to kick-start their season when they host Empoli on Sunday.
Persons:
Stefano Pioli, Massimo Pinca, San Siro, Stefano Pioli's, Tijjani Reijnders, Christian Pulisic, Ruben Loftus, Cheek, Pulisic, Rafael Leao, Loftus, Reijnders, Milan, Sandro Tonali, Olivier Giroud's, Lautaro Martinez, Martinez, Simone Inzaghi, Romelu, Eden Dzeko, Marcus Thuram, Luka Jovic, Fikayo Timori, Simon Kjaer, Jose Mourinho's, Trevor Stynes, Peter Rutherford
Organizations:
Soccer, Juventus, AC Milan, Allianz, Milan, Inter, Serie, Napoli, Lazio, San, Fiorentina, Champions League, Serie A's, France's, Ireland, Juve, Genoa, Lecce, Jose Mourinho's AS Roma, Empoli, Thomson
Locations:
Turin, Italy, Saturday's Milan, Milan, Newcastle, Monza