Czech Muchova was the eighth player to qualify for the season-ending tournament after reaching the Cincinnati final and the U.S. Open semi-final round, losing to American Coco Gauff on both occasions.
"Together with the team and doctors we tried everything till the last moment to resolve my wrist injury," Muchova said in a statement.
"Unfortunately, the time needed for the recovery is longer than we would've hoped for and therefore I had to make this unpleasant decision."
As a result, the ninth-ranked Sakkari will feature in her third straight WTA Finals at this year's event, which starts on Sunday, after reaching the semi-finals a year ago.
Reporting by Amy Tennery in New York; editing by Clare FallonOur Standards: The Thomson Reuters Trust Principles.
Persons:
Karolina Muchova, Coco Gauff, Mike Segar, Maria Sakkari, Czech Muchova, Muchova, Amy Tennery, Clare Fallon
Organizations:
U.S, REUTERS, WTA, Cincinnati, Thomson
Locations:
Flushing Meadows , New York, United States, Czech, Cancun, Greece, New York