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Semaglutide, the compound in the blockbuster drugs Ozempic and Wegovy, dramatically reduced the risk of kidney complications, heart issues and death in people with Type 2 diabetes and chronic kidney disease in a major clinical trial, the results of which were published on Friday. The findings could transform how doctors treat some of the sickest patients with chronic kidney disease, which affects more than one in seven adults in the United States but has no cure. The trial, funded by Ozempic maker Novo Nordisk, was so successful that the company stopped it early. Dr. Martin Holst Lange, Novo Nordisk’s executive vice president of development, said that the company would ask the Food and Drug Administration to update Ozempic’s label to say it can also be used to reduce the progression of chronic kidney disease or complications in people with Type 2 diabetes. Diabetes is a leading cause of chronic kidney disease, which occurs when the kidneys don’t function as well as they should.
Persons: Ozempic, , Katherine Tuttle, Martin Holst Lange, Novo, Subramaniam Pennathur Organizations: University of Washington School of Medicine, Renal Association, The New England, of Medicine, Novo Nordisk, and Drug Administration, Diabetes, Michigan Medicine Locations: United States, Stockholm, The
Diabetes is a key risk factor for kidney disease, which is one of the leading causes of death in the United States and worldwide; about 1 in 3 people with diabetes also has chronic kidney disease, according to the US Centers for Disease Control and Prevention. But new research shows that weekly injections of semaglutide cut the risk of severe outcomes from diabetic kidney disease by about 24%. The new study found even broader related benefits of semaglutide treatment among people with diabetic kidney disease. “Kidney disease attributed to diabetes, or diabetic kidney disease, is one of the most common and deadly complications of diabetes. Yet, unfortunately, there’s very low awareness around it,” said Dr. Katherine Tuttle, chair of the Diabetic Kidney Disease Collaborative for the American Society of Nephrology.
Persons: , Vlado Perkovic, “ Semaglutide, Martin Holst Lange, Katherine Tuttle, ” It’s, Tuttle, semaglutide, It’s, Dr, Sanjay Gupta, White, ” Tuttle Organizations: CNN, Diabetes, US Centers for Disease Control, New England, of Medicine, European Renal Association Congress, University of New, University of New South Wales Sydney, Novo Nordisk, American Society of Nephrology, Providence Inland Northwest Health, Health Sciences, University of Washington, CNN Health Locations: United States, University of New South, Danish, American
A $25 billion market Meanwhile, RBC Capital Markets sees a $25 billion market opportunity for the space. A name Jones likes is Perspective Therapeutics , which he rates outperform. CATX 1Y mountain Perspective Therapeutics year to date Cantor Fitzgerald is also bullish on the name. So it's really an ideal profile," said Piper Sandler analyst Edward Tenthoff, who doesn't cover Perspective Therapeutics. Then there is Lantheus Holdings , which calls itself a radiopharmaceutical-focused company and has a $5.6 billion market cap.
Persons: There's, Eli Lilly, Myers, Jefferies, Andrew Tsai, radiopharma, Oppenheimer, Jeff Jones, FactSet, William Blair, Read, — it's, Andy Hsieh, Gregory Renza, Jones, Cantor Fitzgerald, Louise Chen, it's, Piper Sandler, Edward Tenthoff, Dan Lyons, Janus Henderson, Lantheus, Roanna Ruiz Organizations: Novartis, pharma, Mariana Oncology, Myers Squibb, AstraZeneca, Fusion Pharmaceuticals, RBC Capital Markets, TRT, Therapeutics, Alpha, Janus, Janus Henderson Investors, Lantheus Holdings, Lantheus, Leerink, ~$ Locations: Biopharma, Bristol, Mariana, radiopharma, New Jersey
RBC Capital Markets sees a $25 billion market opportunity for the space. The average analyst rating is hold, with 8% upside to the average analyst price target, according to FactSet. Eli Lilly has an average analyst rating of overweight and 8.3% upside to the average analyst price target, according to FactSet. Stock Chart Icon Stock chart icon AstraZeneca's one-year performanceAstraZeneca shares have an average analyst rating of overweight and nearly 6% upside to the average analyst price target, according to FactSet. Stock Chart Icon Stock chart icon Bristol-Myers Squibb's one-year performance
Persons: It's, Gregory Renza, Renza, Oppenheimer, Jeff Jones, Piper Sandler, Edward Tenthoff, Eli Lilly, Dan Lyons, Janus Henderson, Myers Squibb, William Blair, Matt Phipps, Jefferies, Andrew Tsai, They've, Janus Henderson's Lyons, Jones, Piper Sandler's Tenthoff, Myers Organizations: pharma, RBC Capital Markets, TRT, Novartis, Mariana Oncology, Janus, Janus Henderson Investors, Bristol, RayzeBio, Karuna Therapeutics, AstraZeneca, Fusion Pharmaceuticals, GlobalData's Pharma Intelligence, Pluvicto Locations: Mariana, Bristol
CNN —There is a new coronavirus variant in town. Home tests will likely still detect KP.2, the new coronavirus variant. Grace Cary/Moment RF/Getty ImagesCNN: What should people know about this new variant, KP.2? Wen: Most people who contract the coronavirus will never know what variant is causing their symptoms. CNN: Who should take antiviral treatments if they contract Covid-19?
Persons: Leana Wen, Wen, Grace Cary, Covid Organizations: CNN, US Centers for Disease Control, KP, George Washington University, Getty, Alpha, Beta, CDC Locations: KP, United States, Delta, Covid
Just four months ago, Noland Arbaugh had a circle of bone removed from his skull and hair-thin sensor tentacles slipped into his brain. A computer about the size of a small stack of quarters was placed on top and the hole was sealed. Paralyzed below the neck, Mr. Arbaugh is the first patient to take part in the clinical trial of humans testing Elon Musk’s Neuralink device, and his early progress was greeted with excitement. Neuralink’s staff had to retool the system to allow him to regain command of the cursor. Though he needed to learn a new method to click on something, he can still skate the cursor across the screen.
Persons: Noland Arbaugh, Arbaugh, Elon Organizations: Mario Kart
The announcement is in addition to another $4 billion cost-cutting effort, which Pfizer announced last year as demand for its Covid vaccine and oral drug Paxlovid slumped. One-time costs related to the initial stage of cuts are expected to be about $1.7 billion, including severance for an unspecified number of laid-off employees. Pfizer also expects the program to involve "product portfolio enhancements" and changes to the company's manufacturing and supply network, a spokesperson told CNBC. "The program will focus on streamlining our ways of working, reducing complexity and increasing productivity in Pfizer Global Supply," the spokesperson said in a statement. Pfizer is trying to shore up investor sentiment after its shares fell nearly 50% in 2023, making it the worst-performing pharmaceutical stock last year.
Persons: Paxlovid, Wall, Albert Bourla Organizations: Pfizer, CNBC, Pfizer Global Supply Locations: New York City
CNN —Special counsel David Weiss plans to introduce Hunter Biden’s infamous laptop as evidence against him at his upcoming trial on felony gun charges. Republican officials and right-wing outlets have seized on the laptop’s embarrassing emails and images to attack Biden, the son of President Joe Biden. Hunter Biden’s lawyers have said the files were manipulated, and even sued a computer repair shop owner who publicly released the material. In their own court filings earlier this week, Hunter Biden’s lawyers said they want to contest the authenticity of the materials from the laptop if Weiss brings it up at trial. The testimony, prosecutors say, is “an attempt to substitute the testimony of an expert for the testimony of” the defendant.
Persons: David Weiss, Hunter, Weiss, Biden, Joe Biden, Hunter Biden’s, , ” Weiss ’, , Donald Trump, Hunter Biden, Maryellen Noreika, hasn’t Organizations: CNN, Republican, , FBI, Apple, ” Prosecutors, Prosecutors Locations: Delaware, China, Ukraine
The BackgroundFluoride strengthens tooth enamel, and research suggests that drinking water with added fluoride can reduce cavities by up to 25 percent. Most of the women lived in areas with fluoridated water. The researchers measured the fluoride levels in their urine in a single test during the third trimester. And on average, higher fluoride levels in the mothers’ urine were correlated with a greater risk of behavioral problems in the children. That said, the increases in behavioral scores were relatively small — about two points on a scale from 28 to 100 for overall behavioral problems.
Persons: , Beate Ritz, Patricia Braun, Ashley Malin, Malin, Joseph Braun Organizations: National Institutes of Health, Environmental Protection Agency, JAMA, Fielding School of Public Health, University of Colorado School of Medicine, American Academy of Pediatrics, College of Public Health, Health, University of Florida, Water Watch, Center, Environmental, Brown University Locations: United States, Mexico, Canada, Spain, Denmark, Los Angeles
Structure Therapeutics is an overlooked player in the GLP-1 market, and could one day boast a competitive product and go up against Eli Lilly and the like, according to JPMorgan. Analyst Hardik Parikh initiated research coverage on the clinical stage drug developer with an overweight rating and $65 price target, implying 82% potential upside. According to Parikh, Structure's current $1.7 billion market value undervalues 1290's peak sales opportunity to generate more than $1 billion by 2035. Parikh estimated that Structure will launch 1290 for Type 2 diabetes, or T2D, after 2029. Additionally, Parikh thinks Structure could be an attractive partnership opportunity for larger drug companies looking to get involved in the market for obesity and Type 2 diabetes treatments.
Persons: Eli Lilly, Hardik Parikh, Parikh, Eli Lilly's Organizations: Therapeutics, JPMorgan, pharma, Novo Nordisk, Parikh Locations: T2D
Vivid, disturbing nightmares may be a sign of a newly developing autoimmune disorder or an upcoming flare of existing disease, experts say. Researchers found 3 in 5 lupus patients, and 1 in 3 patients with other rheumatology-related diseases, had increasingly vivid and distressing nightmares just before their hallucinations. Systemic autoimmune diseases often have a range of symptoms, called prodromes, that appear as signs of a sudden and possibly dangerous worsening of the condition. Connect the dots to autoimmune diseaseOn first glance, it would make sense that such neurological manifestations as nightmares would occur if the autoimmune disease impacts the brain, which lupus often does, Sloan said. “In some cases, reporting these symptoms earlier, even if they seem strange and unconnected, may lead to the doctor being able to ‘join the dot’s’ to diagnose an autoimmune disease.”
Persons: , “ He’s, I’m, , Melanie Sloan, ” Sloan, Lupus, ” Jennifer Mundt, ” Mundt, “ I’m, Sloan, David D’Cruz, rheumatologist, that’s, Carlos Schenck, ” Schenck, shouldn’t Organizations: CNN, University of Cambridge, Northwestern University’s Feinberg School of Medicine, Guy’s Hospital, Kings College London, Hennepin County Medical, University of Minnesota Locations: Canadian, United Kingdom, Chicago, Hennepin, Minneapolis
Professional organizations have set this as a guideline for when to reassess whether a treatment is providing clinically meaningful weight loss. People who met with their providers less frequently – and those living in underserved regions with broader health inequities – were more likely to discontinue GLP-1 treatment sooner. But using GLP-1 treatments are still an investment in many ways. These injected medications, called GLP-1 agonists, are in high demand because they have proved to be so effective for weight loss. And experts warn that the GLP-1 treatment process can be different for everyone.
Persons: , Disha, Wegovy, Jody Dushay, Beth, There’s, Razia Hashmi, ” Hashmi, it’s, , Dr, Sanjay Gupta, ” Narang, ” Dushay Organizations: CNN, Endeavor Health, Beth Israel Deaconess Medical Center, Harvard Medical School, Shield, Dandelion Health, CNN Health, Locations: Chicago, , GLP
Injected medications called GLP-1 agonists are in high demand because they have proved to be so effective for weight loss. The difference, which was statistically significant, amounted to a 52% increased risk of being diagnosed with stomach paralysis while on a GLP-1 medication. Compared with those who were not taking a GLP-1 medication, those who did were about 66% more likely to be diagnosed with gastroparesis. This study found that 0.53% of patients on GLP-1 medications were diagnosed with stomach paralysis, or about 1 case of gastroparesis for every 200 people taking the drugs. People taking GLP-1 medications were also more likely to have nausea and vomiting or gastroesophageal reflux disease (GERD) and to be prescribed a proton pump inhibitor.
Persons: gastroparesis, GERD, , Prateek Sharma, Sharma, ” Sharma, Michael Camilleri, , Camilleri, It’s, who’d, Dr, Sanjay Gupta, it’s Organizations: CNN, Drugmaker, Nordisk, University Hospitals, Diabetes, University of Kansas, University of Kansas School of Medicine, American Society, Mayo Clinic, CNN Health Locations: Washington, Cleveland, GLP, Mayo
That was the promise of Cerner, the medical-records company Oracle bought in 2021 for $28.3 billion — Oracle's biggest acquisition. At the time, Cerner managed the electronic health records for a quarter of all American hospitals, including those run by the Pentagon and the Department of Veterans Affairs. Larry EllisonCerner's electronic records, in short, were a deadly disaster for the VA. Never mind the futuristic, AI-driven healthcare system Ellison envisioned. In 2015, it beat out Epic, its main competitor, for a $4.3 billion contract to handle electronic health records for the Defense Department. It had agreed to process tens of millions of crucial medical records, but it couldn't handle the subsequent deluge of data.
Persons: Larry Ellison's, Ellison, Cerner, I'm, Larry Ellison, Neal Patterson, Cerner's, Patterson, Ellison's, they're, David Shulkin, Margaret Albaugh, Cerner couldn't, Charlie Bourg, , Larry, Marc Benioff, Ellison protégé, Mike Wilson, David Agus, oncologist, Agus, he'd, Steve Jobs, Sensei, We've, Georges De Keerle, Cerner —, hadn't, Mike Sicilia, Sicilia, Oracle, Anthony Jones Jr, Jones, Donald Remy, didn't, Seema Verma, Neil Evans, Sara Vaezy, Ed Meagher, haven't, Charlie Monroe —, it's, Charlie Bourg —, Bourg, Charlie Monroe, Monroe, Cathy McMorris Rodgers, grandkids, We're, there's Organizations: Oracle's, Oracle, Pentagon, Department of Veterans Affairs, Cerner, RAND Corporation, RAND, Big Tech, GE, Siemens, Cerner Corporation, Defense Department, Department of Defense, Business, Spokane, Ellison Institute of Technology, Microsoft, Agency, Health, Amazon, Veterans ' Affairs, Oracle Health, Navy, Columbus VA, BI, Life Sciences, Intermountain Health, UPMC, DOD, Seabees Locations: Las Vegas, antiaging, Silicon Valley, Spokane , Washington, Cerner, VistA, Bourg, Washington, Sicilia, Ohio, Columbus, Providence, Spokane, Monroe, CloudWorld
Insider Today: Google's big shakeup
  + stars: | 2024-05-19 | by ( Matt Turner | ) www.businessinsider.com   time to read: +4 min
Sign up to get the inside scoop on today’s biggest stories in markets, tech, and business — delivered daily. If you're interviewing for a job in the coming weeks, check out these five questions to ask at the end. Roaring Kitty; Getty Images; Alyssa Powell/BIThis week's dispatchInvestors go back to the futureAdvertisementStocks hit record highs. And with bitcoin hovering near record highs and the crypto winter seemingly behind us, crypto companies are on the front foot once more. Erdinhasdemir/Getty Images, Choness/Getty Images, Abanti Chowdhury/BIThe hottest jobs right now are blueWant a six-figure salary?
Persons: , Kitty, Alyssa Powell, Keith Gill, Brandon Celi, Abanti Chowdhury, Jobs, Richard A, Rick Doblin, Sundar Pichai Mateusz, Chelsea Jia Feng Google's, shakeup, Sundar Pichai, Pichai, Adam Selipsky's Organizations: Service, Business, Dow, Consumers, Walmart, UPS, FDA, Getty Images, Google, Amazon Locations: Ukraine, East, Silicon
The Conversation —Often a posture assigned to teenagers and disaffected youth, slouching is traditionally considered to be a “bad” posture — with some claiming it will damage your spine and cause pain. But while posture is heavily overlaid with psychological meaning, is it really that bad for our spines if we slouch? There’s also no clear evidence that slouching while sitting at your desk or while using your phone causes damage to the spine. Slouching has been linked to poorer information and memory recall, as well as worse mood when compared to sitting upright. But aside from that, the evidence overwhelmingly suggests there’s no single, ideal or good posture.
Persons: slouching, , , there’s, There’s, it’s, Slouching, Chris McCarthy Organizations: CNN, Manchester Metropolitan University
Regular sauna sessions may help alleviate depression, a new study shows. 11 out of 12 no longer met depression criteria after the study. AdvertisementThe next time you need to boost your mood: Head to the sauna . According to a new study conducted by Ashley Mason, a clinical psychologist at the UC San Francisco Osher Center for Integrative Health, regular sauna sessions might benefit individuals with depression. By the end of the trial, 11 out of the 12 participants no longer met the criteria for major depressive disorder.
Persons: , Ashley Mason, Mason Organizations: Service, UC San Francisco Osher Center, Integrative Health, Business
There, a startup called Conceivable Life Sciences is automating the IVF lab from start to finish. Conceivable Life SciencesEleven women so far have become pregnant with help from one or more of these Conceivable robots. Conceivable Life Sciences"No baby, no fee"Today, IVF demand is surging, despite the treatment being slow, uncertain, and expensive. Conceivable's future IVF lab. Conceivable Life SciencesFrom prayer to AIHalf a continent away, a physician was growing frustrated by the constraints of his job.
Persons: , robotically, embryologist Jacques Cohen, Cohen, Joshua Abram, Conceivable's, Abram, Lora Shahine, Emma wasn't, Emma, Alan Murray, Murray, — embryologists, that's, Alejandro Chávez, Badiola, REI, didn't, Conceivable's cofounders, Dr, REIs, What's, Langham, Conceivable's cofounders tinker, Tesla, Brian Bixon, Gerardo Mendizabal, Ruiz, Bixon, Carla Patricia Barragan Álvarez, OBGYNs, aren't, Eduardo Hariton, Hariton Organizations: Service, Business, Sciences, BI, New York City, pipettes, Life Sciences, San, Langham Hotel, Quest Diagnostics Locations: Guadalajara, Mexico, New York, Seattle, pipettes, Petri, San Francisco, London, Abram, Mexico City
Blood biomarkers of telltale signs of early Alzheimer’s disease in the brain of his patient, 55-year-old entrepreneur Simon Nicholls, had all but disappeared in a mere 14 months. “I don’t use the term ‘reverse.’ I don’t know what reverse means when it comes to the field of Alzheimer’s,” Isaacson said. ‘It was time to turn to my brain’Slowly, Nicholls’ heart condition began to improve, but the bad news didn’t end there. A brain scan found telltale signs of vascular damage in Nicholls’ brain, which occurs when the tiniest blood vessels are starved of oxygen. Not only was Nicholls blood negative for amyloid and tau, the test suggested that his brain amyloid might be normal, with no distinguishable signs of the disease.
Persons: Sanjay Gupta, Anderson Cooper ”, Richard Isaacson, Simon Nicholls, , , Isaacson, “ Simon, ” Isaacson, Nicholls, ” Nicholls, Anderson Cooper, It’s, APOE4, Simon, ” Simon Nicholls, Sylver, Lewy, Richard Isaacson ‘, APOE ε4, “ I’ve, Isaacson doesn’t, “ I’m, Shocked, Dr, we’d, “ It’s, Salvadore, Richard Isaacson “, ‘ It’s, I’m Organizations: CNN, telltale, ” CNN, Boca Raton Locations: Boca Raton , Florida, New York City, Florida, Nature, Miami, Isaacson’s Florida, tirzepatide
It's peak allergy season in several states on the East Coast, including New York, and you, or your loved ones, may be sneezing, coughing and feeling more miserable than usual this year. More severe symptoms of seasonal allergies this spring are likely due to a warmer winter and an earlier start of allergy season, says Dr. Purvi Parikh, an allergist and immunologist with the Allergy & Asthma Network. And the cause of this longer, more intense allergy season? "There's higher amounts of pollen due to rising greenhouse gasses and more CO2 in the air, which plants thrive off of," Parikh tells CNBC Make It. Here are some effective ways to alleviate your allergy symptoms and still enjoy the spring.
Persons: Purvi, Shelby Harris, Harris Organizations: Allergy, Asthma, CNBC Locations: East Coast, New York
This time, he stuck to the spot market, both day trading and swing trading. AdvertisementHis next filter is stocks trading above $1 to avoid any really volatile penny stocks. All this is done before the stock market opens. He doubles down with this filter by using it during earnings season as well. He determined that $2.48 was a resistance point based on where selling pressure appeared during the previous month's chart.
Persons: James Hatzigiannis, William O'Neill, Hatzigiannis, Mark, Goverdhan Gajjala Organizations: Service, Nike, Business, BI, Photonics Corp, L3Harris Technologies, Rail, Systems Locations: Chicago
Crosby Health just raised $2.2 million in seed funding led by Amplo Ventures. The startup is building a large language model to help providers track insurance appeals. We got an exclusive look at the eight-slide pitch deck the startup used to raise its seed round. download the app Email address Sign up By clicking “Sign Up”, you accept our Terms of Service and Privacy Policy . Crosby Health, an AI startup building a clinical, large language model to help healthcare providers track insurance appeals, recently announced it raised $2.2 million in seed funding led by Amplo Ventures.
Persons: Crosby, Organizations: Crosby Health, Amplo Ventures, Service, , NOMO Ventures, Business
One constant refrain at these protests is the call for college endowment funds to divest from Israel and the many American companies that do business there. Tech companies such as Google and Amazon and defense contractors such as Boeing and Lockheed are on that list. "These endowments are famously opaque," said Alison Taylor, clinical associate professor at New York University's Stern School of Business. However, many universities have ignored the calls to divest from Israel or companies that do business there. Watch the video above to learn more about how divesting from Israel and companies who do business there would actually work, and how it would affect the tens of billions of dollars at stake in college endowment funds.
Persons: Alison Taylor, University's, Witold Henisz, there'll Organizations: Tech, Google, Boeing, Lockheed, University's Stern School of Business, University of California, Universities, The Wharton School, University of Pennsylvania Locations: Israel, New, Berkeley
New York CNN —Elon Musk’s brain implant startup Neuralink is accepting applications for a second human trial participant to test its device, the billionaire said on X Friday. Neuralink said that the threads connecting the chip to Arbaugh’s brain had retracted, causing performance issues, although the company said it made adjustments to improve its function. Still, Arbaugh says the implant — which allows him to control a computer cursor with his brain — has changed his life. This is the next step forward of helping people with paralysis.”Now, Neuralink is seeking more people like Arbaugh to test out its brain chip. About a month after the operation, Musk said Arbaugh could control a computer mouse with his brain.
Persons: New York CNN — Elon, Neuralink, Noland Arbaugh, Arbaugh, ” Arbaugh, , ” Neuralink, Musk, , DJ Seo, Noland, – CNN’s Jordan Valinsky Organizations: New, New York CNN, Morning America, Morning Locations: New York, Morning America
FLiRT variants are offshoots of the JN.1 variant — all part of the broader Omicron family — that caused this winter’s wave. The mutations of the FLiRT variants make increased transmissibility — and a possible summer wave — a real threat. “We learned from the laboratories that FLiRT variants appeared, so far, to be as transmissible as the other Omicron subvariants, which means they’re really quite contagious. As of May 1, the requirement for all hospitals to report Covid-19 data to the federal government has expired. While the FLiRT variants pose some risk this summer, experts remain focused on what might happen in the fall.
Persons: CNN —, , Andy Pekosz, “ We’ve, William Schaffner, ” Schaffner, it’s, ” Pekosz, , Dr, Sanjay Gupta, we’ve Organizations: CNN, US Centers for Disease Control, Data, Johns Hopkins Bloomberg School of Public Health, Vanderbilt University, Schaffner’s Vanderbilt University Medical Center, CDC, JAMA, CNN Health, JN, US Food Locations: United States, Covid
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