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Costfoto | Future Publishing | Getty ImagesLONDON — Pharmaceutical company AstraZeneca on Tuesday said it planned to increase its total revenue to $80 billion by 2030 — up 75% from $45.8 billion in 2023. AstraZeneca will focus on its oncology, biopharmaceuticals and rare diseases businesses and expects to release an additional 20 medicines in the next six years. "Many of them have the potential to be $5 billion drugs," Sarin noted. A company statement detailed that this revenue figure could be hit annually for many of the new medicines in peak years. "For the entire market to get replaced it will take time, but we think we have the technology today to start replacing them," Sarin told CNBC.
Persons: CNBC's Arabile Gumede Organizations: Astrazeneca, Artificial Intelligence, — Pharmaceutical, AstraZeneca, CNBC, U.S . FDA, Pharmaceuticals, Investments Locations: Shanghai, China, Europe, London, Singapore
So it goes for Menendez, who is likely pleased to have his legal drama playing out in relative obscurity. More recently, Fetterman mocked the senator’s defense, which relies in part on pointing the finger of blame on Nadine Menendez, his wife. Republicans in Washington, as they’ve done during these first two weeks of the Menendez trial in New York, have been consistently deferential to the New Jersey Democrat. Rep. Andy Kim, a popular Democrat from South Jersey, is expected to win the nomination to succeed Menendez. Andrew Giuliani, pressed for a thought on the senator’s trial or the allegations against him, shrugged.
Persons: New York CNN — Andrew Giuliani, Donald, , Rudy Giuliani squinted, , ” He’s, Sen, Bob Menendez’s, , Michael Cohen, Daniels, Menendez, Trump, Donald Trump Jr, Attorney Alvin Bragg, Ronny Jackson, Bob Costello, Pam Bondi, Missouri Sen, Eric Schmitt, Matt Whitaker, Sebastian Gorka, Gov, Dan Patrick, Jackson, María Elvira Salazar, Troy Nehls, Dale Strong, Daniel Webster of, Vladimir Putin’s, Cory Booker, Chuck Schumer, John Fetterman, George Santos, Fetterman, Nadine Menendez, ” Fetterman, Jake Tapper, Mitch McConnell, ” North Dakota Sen, Kevin Cramer, he’s, Andy Kim, Andrew Giuliani, haven’t, ” CNN’s Sabrina Souza Organizations: New, New York CNN, New York, Manhattan Criminal, Court, Republican, Democrat, The New, The New Jersey Democrat, Foreign Relations, Trump, Democratic, Manhattan, Attorney, Texas, Dale Strong of, Pennsylvania Democrat, New York Rep, , Union, , Republicans, New Jersey Democrat, Democrats, GOP, ” North, Politico Locations: New York, Lower Manhattan, Manhattan, The, The New Jersey, Menendez’s, Florida, Sebastian Gorka , Texas, María Elvira Salazar of Florida, Texas, Dale Strong of Alabama, Daniel Webster of Florida, North Korea, Vladimir Putin’s Russia, New Jersey, Pennsylvania, Washington, Egypt, , “ State, Israel, ” North Dakota, South Jersey, New York City
Here are four big questions facing Menendez, his lawyers and federal prosecutors as the trial intensifies. How hard does the defense lean on Nadine Menendez? The other half of their telling, in short, is that Nadine Menendez was the one pulling the strings — and hiding it from her husband. Republicans have been surprisingly absent from the hoopla around the Menendez trial. This dynamic could change later this week or next when Trump’s trial is expected to reach its denouement.
Persons: Sen, Bob Menendez’s, , Menendez, Nadine, Wael Hana, Fred Daibes, Andy Kim, Lara Pomerantz, , Pomerantz, James Bret Tate, Hana’s, Prosecutors, Nadine Menendez, Avi Weitzman, ” “, ” Weitzman, Weitzman, , Candace E, Hana, Will, hasn’t, Donald Trump Organizations: CNN, New, New Jersey Democrat, Garden, Democratic, Capitol, US Department of Agriculture, of Agriculture, USDA, Will Republicans, GOP, Republicans Locations: New Jersey, Egypt, Qatar, New York, Manhattan, Egyptian American, Cairo, Hana’s New Jersey, New York City
On Wednesday, a lawyer representing Senator Robert Menendez in his bribery trial painted a picture of a marriage cloaked in secrecy and deception, casting the senator’s wife, Nadine Menendez, as an opportunist who traded on his name. Less than 24 hours later, Mr. Menendez was projecting a new message: He was a protective husband asking for privacy for his wife, who, he revealed for the first time, was being treated for breast cancer. “We are of course concerned about the seriousness and advanced stage of the disease,” Mr. Menendez, 70, said in the statement. “We hope and pray for the best results.”The timing of the announcement, issued by his Senate office, punctuated a remarkable first week of trial. And the revelation served to shine a newly intense spotlight on a couple whose fates are intertwined — but whose priorities may not be.
Persons: Robert Menendez, Nadine Menendez, Menendez, Mr
US Senator Bob Menendez, Democrat of New Jersey, and his wife Nadine Arslanian, arrive at the US District Court, Southern District of New York, in New York City on September 27, 2023. Nadine Menendez, the wife and co-defendant of Sen. Robert Menendez, has been diagnosed with breast cancer, the Democratic lawmaker revealed Thursday during his trial on federal corruption charges. Nadine Menendez "had financial concerns that she kept from Bob," he said. The attorney advised the jurors that every time they hear evidence about Nadine Menendez, they should ask themselves, "What did Bob know?" "Every action Senator Menendez took was to help his constituents," he said.
Persons: Bob Menendez, Nadine Arslanian, Nadine Menendez, Sen, Robert Menendez, Menendez, Nadine, ” Menendez, Nadine Menendez's, Wael Hana, Fred Daibes, Avi Weitzman, Weitzman, Bob, Waldo, Laura Pomerantz, Pomerantz Organizations: Democrat, Court, Southern District of, Democratic, NBC Locations: New Jersey, Southern District, Southern District of New York, New York City, Manhattan, Jersey, U.S
Madonna honored her mother, who died from breast cancer at 30, in a Mother's Day Instagram post. "Nobody told me my mother was dying," the singer, 65, wrote in the caption, recounting her childhood. download the app Email address Sign up By clicking “Sign Up”, you accept our Terms of Service and Privacy Policy . AdvertisementMadonna paid tribute to her mother, who died aged 30 after a battle with breast cancer, in an emotional Mother's Day post. On Sunday, the pop star uploaded an Instagram post and recalled what it felt like as a child.
Persons: Madonna, Organizations: Service, Business
Olivia Munn told Vogue she underwent egg freezing three times in her life. AdvertisementOlivia Munn, 43, says she has frozen her eggs on three separate occasions in her life, most recently in response to her breast cancer diagnosis. She shared that she underwent egg freezing at ages 33, 39, and 42. Clearly, the month we did at 39 was not a good month," Munn told Vogue. Due to the rise in hormone levels, there are side effects associated with egg freezing, including mood swings, headaches, and nausea.
Persons: Olivia Munn, , Munn, John Mulaney, uteruses, Raegan McDonald, Mosley, Chrissy Teigen, John Legend, Paris Hilton, Rebel Wilson Organizations: Vogue, Service, Power, American College of Obstetricians
CNN —Actress Olivia Munn continues to share her journey since being diagnosed with breast cancer last year. In a new interview with Vogue, published Sunday, the “Newsroom” actress revealed that she recently had a hysterectomy. Munn first revealed that she was diagnosed with a form of breast cancer known as Luminal B cancer in March. The cancer was found in both of her breasts, and Munn’s treatment included a double mastectomy. “This journey has made me realize how grateful I am to have options for not only fighting cancer,” she said, “but also having more children if we want.”
Persons: Olivia Munn, , Munn, , John Mulaney, Malcom, “ John, Mulaney “ Organizations: CNN, Vogue
Wedbush reiterates Apple as outperform Wedbush said it's standing by its outperform rating on shares of Apple . Bank of America reiterates Palantir as buy Bank of America said it's standing by its buy rating on shares of Palantir. Bank of America initiates Apogee Therapeutics at buy Bank of America said the biotech company has best-in-class potential. Bank of America upgrades Bumble to buy from neutral Bank of America sees "multiple expansion" for the dating app company. Bank of America reiterates Walmart as buy Bank of America said it's bullish heading into Walmart earnings on May 16.
Persons: Bernstein, Wedbush, Palantir, Wells, CRNC, Stifel, TD Cowen, Morgan Stanley, Raymond James, it's, Bumble, Lear, Tesla, Oppenheimer, Guggenheim Organizations: Nvidia, Citi, Cheesecake, Apple, Worldwide, " Bank of America, Bank of America, Mizuho, Apogee Therapeutics, Warner Brothers Discovery, HSBC, TPG, of America, Dominion, underperform Bank of America, Dominion Energy, Barclays, Nike, Walmart, Supercenters, Moffett Locations: WWDC, Palantir, OW, U.S
Barclays thinks Relay Therapeutics stock can benefit from progress in drug tests to get a proposed breast cancer treatment approved, boosting the stock. Relay stock has slumped 40% in 2024. "We believe the 2H update will help show the superior efficacy/safety profile for Relay's PI3Kalpha (RLY-2608) over existing PI3Kalpha inhibitors like alpelisib and inavolisib," Lawson said. Barclays sees a 70% chance of positive data emerging from an expanded Phase 1 study of RLY-2608 (+fulvestrant) in advanced HR+/HER2- breast cancer. That outcome, "all else equal, could potentially drive the stock up $5 while negative data could drive the stock down $2," the bank said.
Persons: Peter Lawson, Relay's, Lawson Organizations: Barclays, Therapeutics
CNN —An influential group of medical experts, the US Preventive Services Task Force, recommended last week that most women receive a mammogram starting at age 40. People should now starting getting mammograms at age 40, according to new recommendations. According to a study in the journal Lancet Oncology, the mortality from breast cancer could be lowered by starting mammograms earlier, at age 40. A woman who has a sister, mother or other first-degree relative with breast cancer has double the average risk of breast cancer. Wen: Someone who has a family history of breast cancer may be recommended for genetic testing.
Persons: Leana Wen, Wen Organizations: CNN, US Preventive Services Task Force, George Washington University, Getty, American Cancer Society, Preventive, Force, White, Oncology, The American College of Obstetricians, American, of Radiology Locations: United States
I've always known that my parents were older than the parents — and occasionally even the grandparents — of my peers. Having older parents than my peers was both rewarding and challenging while growing up. Almost any child with older parents, regardless of the generation they were born into, can tell you they've imagined what taking care of their parents would look like. To my surprise, many of my Gen Z friends knew exactly what I was going through. You rarely tell the "outside" — be it your extended family or friends, what's going on "inside" — or in the home.
Persons: I've, , what's, I'd
Pamela Anderson broke her no-makeup streak at the 2024 Met Gala. AdvertisementAfter a slew of bare-faced public appearances, Pamela Anderson finally ditched the no-makeup look for her Met Gala debut. Pamela Anderson ditched her no-makeup look for her first Met Gala appearance. And since then, I just felt, without Alexis, it's just better for me not to wear makeup," Anderson said. Reflecting on her Met Gala debut, Anderson told the Times that it "means a lot" to her that she was invited.
Persons: Pamela Anderson, Oscar, la, Pat McGrath, Anna Wintour's, Anderson, , Cindy Ord, MG24, McGrath, Theo Wargo, smokey, Elle, Alexis Vogel, Alexis, it's, Noel Stewart headpiece, Marleen Moise, Noel Stewart —, Anna Wintour Organizations: Service, British Vogue, New York Times, Times, Met
When Kris Hallenga was diagnosed with Stage 4 breast cancer — the most advanced form — at 23, questions swirled through her head: “Why didn’t anyone tell me to check my boobs? Why didn’t I know I could get breast cancer at 23?”If she hadn’t known that she could have breast cancer so young, there was a very good chance others were equally uninformed, she said in a 2021 interview with The Guardian. She spent the next 15 years educating young people about early detection through her nonprofit organization, CoppaFeel, and in a 2021 memoir, “Glittering a Turd.”On Monday, CoppaFeel announced that Ms. Hallenga had died at 38. A spokesman for the organization said she had died at home in Cornwall, England, and that the cause was breast cancer. “Survival was never enough,” she said during a publicity tour in 2021.
Persons: Kris Hallenga, swirled, , CoppaFeel, Hallenga, , ‘ I’m, I’m, Organizations: Guardian Locations: Cornwall, England
An analogy for understanding the development of AI drugs can be found in the mechanisms of ChatGPT. As a result, it's a drug discovery process that has a 90% failure rate. Some of the noted flaws of generative AI, its propensity to "hallucinate" for example, could prove to be powerful in drug discovery. AI is learning to distinguish drugs from non-drugs, and to create new drugs, in the same way that ChatGPT can create sentences, Ellington said. Now, AI models are helping narrow down the possibilities, so scientists more quickly know the optimal modifications to try.
Persons: ChatGPT, Kimberly Powell, Google's, , AlphaFold, Powell, Rau, Lilly, Eli Lilly, Diogo Rau, It's, Amgen, Andy Ellington, Ellington, Daniel Diaz, Diaz, We've Organizations: Nvidia, CNBC Technology, Summit, University of Texas, Austin, NVIDIA, biosciences, UT's Institute, Foundations of Machine, Cadence Locations: Nature
Olga Fikotova Connolly, who won a gold medal in track and field for Czechoslovakia in the 1956 Melbourne Olympics, watched Harold Connolly of the United States win one the next day, and, in March 1957, married him as the highlight of a storybook Cold War romance, died on April 12 in Costa Mesa, Calif. She was 91. She died in her son Jim’s home, where she had been receiving hospice care, Ms. Connolly-Freund said. The governing body European Athletics said Olga Connolly had been the last living female gold medalist from the Melbourne Games. Her competitive record as a discus thrower was exceptional: five Olympic Games (four representing the United States as an American citizen), five American championships and four American records. Harold Connolly, a hammer thrower from Massachusetts, competed in four Olympics.
Persons: Olga Fikotova Connolly, Harold Connolly, Merja Connolly, Freund, Jim’s, Connolly, Olga Connolly Organizations: Czechoslovakia, United States, Melbourne Games, Olympic Games Locations: Costa Mesa, Calif, United States, American, Massachusetts
Citing rising breast cancer rates in young women, an expert panel on Tuesday recommended starting regular mammography screening at age 40, reversing longstanding and controversial guidance that most women wait until 50. The panel, the U.S. Preventive Services Task Force, finalized a draft recommendation made public last year. In 2009, the task force raised the age for starting routine mammograms to 50 from 40, sparking wide controversy. But now breast cancer rates among women in their 40s are on the rise, increasing by 2 percent a year between 2015 and 2019, said Dr. John Wong, vice chair of the task force. The panel continues to recommend screening every two years for women at average risk of breast cancer, though many patients and providers prefer annual screening.
Persons: John Wong Organizations: U.S . Preventive Services Task Force Locations: U.S, United States
It’s expected to become a Schedule III controlled substance, a classification shared by prescription drugs such as ketamine and Tylenol with codeine. Here’s what else you might have missed during your busy day:5 thingsKeith Davidson, who represented Stormy Daniels and Karen McDougal, is questioned. Jane Rosenberg1️⃣ Trump on trial: Donald Trump removed the online posts that a judge ruled violated his gag order in the New York criminal hush money case. The former president also was fined $9,000, and a former attorney who represented Stormy Daniels and Karen McDougal testified. 5 Things PM is produced by CNN’s Tricia Escobedo, Meghan Pryce and Kimberly Richardson.
Persons: ane R, Ed, bil, Lis, r., Gupta, Loo, Cheng S Organizations: acc, ld, CNN
I'm an only child and my mom had me when she was 20. As her only child I was responsible for taking her to all her appointments and caring for her. download the app Email address Sign up By clicking “Sign Up”, you accept our Terms of Service and Privacy Policy . She inherited a rare gene mutation that makes it more likely a person will get cancer at a young age. Before learning about her cancer, the chances we'd end up in the same retirement home seemed fairly high.
Persons: , she'd, I've, I'm Organizations: Service
The "My Heart Will Go On" singer, who revealed in 2022 that she was diagnosed with stiff-person syndrome, spoke to Vogue France about her recent life and her thoughts on when she'll be able to perform again. Stiff-person syndrome is a neurological disorder that can cause symptoms such as muscle stiffness and spasms. While there is no cure for stiff-person syndrome, there are ways for patients to manage their condition. Related storiesDion shared in the interview that she undergoes "athletic, physical, and vocal therapy" five days a week as part of her treatment plan. Although it was initially difficult for her to come to terms with her diagnosis, the singer says she is learning to live with stiff-person syndrome.
Persons: , Dion, she'll, I've, Celine Dion, Shannen Doherty, Doherty, Olivia Munn, Munn Organizations: Service, Eiffel, Vogue France, Business Locations: North America, Beverly Hills
They initially mulled over relocating to four potential destinations – Ghana, Sweden, Mexico, and of course, Costa Rica. There’s something energetic about being in Costa Rica.”‘Serendipitous’ move"There’s something energetic about being in Costa Rica," says Ward-Hopper. The community really looked out for each other.”New additionTheir son Nicolai was born in Costa Rica in 2020. “So for us it is more affordable, it’s getting more expensive as more people move to Costa Rica. “I guess we’re more nomadic than stationary, but Costa Rica feels like home.”
Persons: Kema, Hopper, Nicholas Hopper, Aaralyn, , , I’d, Hurricane Harvey, Houston, Ward, they’d, we’ve, Nicolai, ” “, it’s, she’s, “ I’m, Costa, Costa Rica Organizations: CNN, Central American, CNN Travel, Loma Locations: Costa Rica, Houston , Texas, Houston, Ghana, Sweden, Mexico, “ Costa Rica, – Costa Rica, , Pueblo Nuevo, California, Sardinia, Okinawa, Nicoya, Costa Rican, Latin America, Colombia, Brazil, Costa
CNN —What is one of the earliest and enduring subjects in art and media — as well as one of the most censored? And these are all themes explored broadly in the exhibition “Breasts,” a robust survey on display at the 60th Venice Bienniale. “It’s very intimate, so it’s perfect for international artists to develop a dialogue with each other,” she said in a video call. “Artists keep going back to it.”“It’s been a wonderful moment to contemplate my own relationship with the meaning of breasts,” she added of the show. Scroll to see artworks from the show, which will run through November 24 at the Palazzo Franchetti.
Persons: they’re, Cindy Sherman, Robert Mapplethorpe, Salvador Dalí, Anna Weyant, Chloe Wise, Lakin, Carolina Pasti, , , Bernardino del Signoraccio, Sherman, Jesus, Del, Raphael, Flavio Gianassi, we’ve, Teniqua Crawford, “ It’s, Todd White, Europe Allen Jones, Maggiore Allen Jones, Maggiore Laura Panno, Christopher Bucklow, Tetrarch, Claudia, Schiffer, Christopher Bucklow Giorgio de Chirico, Nudo, Turin Louise Bourgeois Organizations: CNN, Venice Bienniale, Artists, Buchanan Studio, Maggiore Locations: Venice, Europe, Italy
Mammograms can miss tumors in women with dense breast tissue. So for these patients, doctors often include a second scan — ultrasound, for example, or an M.R.I. Though many women see the extra scan as a routine form of prevention, Medicare won’t pay for it, and some patients are left to pick up a hefty tab. But the clinic’s staff said that while her mammogram would be fully covered by Medicare, a so-called supplemental ultrasound was not. “I just don’t understand how something that has been the recommended diagnostic test for years is suddenly not covered by Medicare,” she said.
Persons: Mammograms, Joellen Sommer, Sommer, , Organizations: Medicare Locations: Manhattan
Olivia Munn, 43, reflects on her emotional experience after undergoing a double mastectomy due to breast cancer. NEW LOOK Sign up to get the inside scoop on today’s biggest stories in markets, tech, and business — delivered daily. AdvertisementOlivia Munn, 43, remembers the shock she experienced when she saw her body for the first time after a double mastectomy. Munn said she underwent four surgeries, including a 10-hour double mastectomy, as part of her treatment plan. I can tell my children that they don't need to fear they will lose me to breast cancer," Jolie wrote.
Persons: Olivia Munn, Munn, , it's, Sharon Osbourne, I've, Osbourne, Angelina Jolie, Jolie Organizations: Service, New York Times, for Disease Control
Does this mean people should start screening for cancer at younger ages? In the United States, lung cancer, colorectal cancer, pancreatic cancer and breast cancer are the four top causes of cancer deaths. For instance, in the United States, the US Preventive Services Task Force recommends that people begin colon cancer screenings at age 45. One in 3 people who are eligible for colon cancer screenings have never received any screening exams, according to the American Cancer Society. As little as one or two minutes of vigorous exercise a day can lower cancer risk, as can reducing ultraprocessed food.
Persons: Leana Wen, Wen, hasn’t, It’s Organizations: CNN, American Cancer Society, George Washington University, Oncology, US Preventive Services Task Force, Brigade Locations: United States
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