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CNN —With another pricey Alzheimer’s disease treatment expected to receive an approval decision soon, the nonprofit Alzheimer’s Association has published the final version of its new diagnostic criteria for the disease. Together with another protein, tau, which makes fibrous tangles that block the communication of nerve cells, they are considered a hallmark of Alzheimer’s disease. “There’s no evidence for it,” said Dr. George Perry, a neurobiologist and editor of the Journal of Alzheimer’s Disease. Two members of the panel were employees of the Alzheimer’s Association, which also takes funding from pharmaceutical companies. Widera says he hopes that in the next round of guidelines, the Alzheimer’s Association will consider the risks involved.
Persons: There’s, , donanemab, , , George Perry, Adriane Fugh, Berman, haven’t, Maria C, Carrillo, Alzheimer’s, It’s, Eric Widera, Widera, it’s, Aduhelm, Karl Herrup, Clifford Jack, ” Jack, “ It’s, Niles Franz, ” Franz, Dr, Sanjay Gupta, Franz, ” Widera Organizations: CNN, Alzheimer’s Association, Food and Drug Administration, FDA, Georgetown University, University of California San, American Geriatrics Society, Abbott Labs, University of Pittsburgh School of Medicine, Mayo Clinic, Nature Medicine, federal National Institute, Aging, Alzheimer’s Association International, National Institute, National Institutes of Health, NIA, Alzheimer’s, National Academy of Medicine, CNN Health, Association Locations: University of California San Francisco
“I feel myself the most unhappy and wretched creature in the world,” Franz Schubert, suffering from syphilis and reeling from professional failures, wrote in March 1824 to his friend, the painter Leopold Kupelwieser. “I seem once again,” Schubert, then 27, wrote in his letter, “to have composed two operas for nothing.”He wouldn’t return to the genre again. And even after his death in 1828, at 31, when many of his works enjoyed posthumous adulation and were performed widely, none of his theatrical undertakings entered the standard repertoire. It’s surprising that opera eluded Schubert, who by most counts started about 20 stage works, completed fewer than a dozen and saw the premieres of just two. After all, he wrote some of the most beautiful vocal music in the repertoire: the song cycles “Die Schöne Müllerin” and “Winterreise,” and hundreds of beloved lieder like “Gretchen am Spinnrade” and “Ave Maria.”
Persons: ” Franz Schubert, Leopold Kupelwieser, , Schubert, , ” Schubert, “ Gretchen, Spinnrade Locations: Vienna, , Maria
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